| Potential role of fluorine-18-deoxyglucose (FDG) positron emission tomography (PET) in the staging of primitive and recurrent medullary thyroid carcinoma. | |
| | |
MedLine Citation:
|
PMID: 9413806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated 5 MTC patients, 3 preoperatively for staging purpose, and 2 after surgery, during the follow-up, because of the persistence of elevated serum tumoral markers. FDG PET results were compared with conventional radiologic (US, CT scan, MRI) and scintigraphic non-invasive techniques (99mTc-MIBI and 99mTc-MDP scans). In all the 3 patients preoperatively studied, PET, as well as the other imaging modalities, detected the primitive tumor and the loco-regional lymphnode metastases. Furthermore, in one case, PET was the only technique that revealed an additional localization to the lungs. One false negative result was recorded with PET, as well as with the conventional imaging, in a MTC patient with a MEN II syndrome and with some liver micrometastases, 2 to 5 mm sized, showed only at laparotomy. PET was the only method capable of early visualizing a mediastinal relapse of the tumor in one of the 2 patients studied during the follow-up. This patient was re-operated and serum calcitonin levels became undetectable. On the basis of our preliminary results on MTC, PET with FDG seems to be an accurate, non-invasive technique, for staging purpose before surgery, and, during the follow-up for visualizing tumoral spread in patients with increased serum tumoral markers. |
| | |
Authors:
|
P Gasparoni; D Rubello; G Ferlin |
Related Documents
:
|
20514576 - Integrated positron emission tomography-computed tomography does not accurately stage i... 17895786 - Three-dimensional mdct gastrography compared with axial ct for the detection of early g... 14530496 - Pet scans in the staging of lymphoma: current status. 17694556 - Interpretability of pet/ct imaging in head and neck cancer patients following composite... 8827806 - Fast fluid-attenuated inversion recovery (fast-flair) of ischemic lesions in the brain:... 19826206 - Interaction of mri field gradients with the human body. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of endocrinological investigation Volume: 20 ISSN: 0391-4097 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 1997 Oct |
Date Detail:
|
Created Date: 1998-01-20 Completed Date: 1998-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: ITALY |
Other Details:
|
Languages: eng Pagination: 527-30 Citation Subset: IM |
Affiliation:
|
Dipartimenti di Endocrinologia, Ospedale di Castelfranco V.to (TV), Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Carcinoma, Medullary / radionuclide imaging*, surgery Female Fluorine Radioisotopes Fluorodeoxyglucose F18* Humans Male Middle Aged Neoplasm Recurrence, Local Neoplasm Staging* Thyroid Neoplasms / radionuclide imaging*, surgery Tomography, Emission-Computed* |
| Chemical | |
Reg. No./Substance:
|
0/Fluorine Radioisotopes; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy.
Next Document: Sporadic amplification of the insulin receptor gene in human breast cancer.