Document Detail


Potential role of endothelial progenitor cells in the pathophysiology of heart failure: clinical implications and perspectives.
MedLine Citation:
PMID:  16860805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endothelial dysfunction is thought to play a major role in the development and clinical complications of heart failure. Endothelial progenitor cells (EPCs) have been shown to provide an endogenous repair mechanism to counteract detrimental risk factor-induced effects and replace dysfunctional endothelium. The number and in vitro function of EPCs is altered in patients with heart failure, as a result of its pathophysiological mechanisms. EPCs could represent a substitutional marker to guide preventive or therapeutic interventions in this disease. Enhancing the number and functional capacity of EPCs with targeted interventions may elicit functional improvement in individuals with heart failure. However, the exact role of EPCs in heart failure and their potential therapeutic implications still remain to be elucidated.
Authors:
Ioannis Andreou; Dimitris Tousoulis; Costas Tentolouris; Charalambos Antoniades; Christodoulos Stefanadis
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-07-24
Journal Detail:
Title:  Atherosclerosis     Volume:  189     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-01-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
Affiliation:
Athens University Medical School, A' Cardiology Department, Hippokration Hospital, S. Karagiorga 69, Glifada 16 675, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Endothelium, Vascular / pathology,  physiopathology*
Heart Failure / pathology*,  physiopathology*
Humans
Neovascularization, Pathologic / pathology,  physiopathology
Risk Factors
Stem Cells / pathology*
Vascular Resistance / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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