| Potential role of anti-GAD antibodies in abnormal eye movements. | |
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MedLine Citation:
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PMID: 15826997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutamic acid decarboxylase (GAD) catalyzes the conversion of glutamic acid to gamma-aminobutyric acid (GABA). Autoantibodies directed against GAD (antiGAD-Ab) have been described in patients with insulin-dependent diabetes mellitus, stiff-man syndrome, and in a few patients with progressive cerebellar ataxia. The presence of these autoantibodies suggests an autoimmune pathophysiological mechanism for the neurological manifestations in these disorders. However, the exact role of antiGAD-Ab and GABAergic neurotransmission in the pathogenesis of the neurological manifestations, particularly in progressive cerebellar ataxia, is not fully understood. The cases of two patients with subacute cerebellar ataxia associated with antiGAD-Ab presenting with abnormal eye movements are reported. One patient presented a periodic alternating nystagmus (PAN), whereas the other presented a downbeat nystagmus (DBN) and slow vertical saccades. The potential role of antiGAD-Ab and the resultant GABAergic neurotransmission deficit in oculomotor manifestations is discussed. |
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Authors:
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Caroline Tilikete; Alain Vighetto; Paul Trouillas; Jérome Honnorat |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1039 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-13 Completed Date: 2006-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 446-54 Citation Subset: IM |
Affiliation:
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Neuro-Ophthalmology Unit, Hôpital Neurologique, Hospices Civils de Lyon, 59 Bd Pinel, 69 677 Bron Cedex, France. tilikete@lyon.inserm.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autoantibodies / blood* Eye Movements / physiology* Female Glutamate Decarboxylase / immunology* Humans Middle Aged Nystagmus, Physiologic / immunology Ocular Motility Disorders / immunology* Oculomotor Nerve Diseases / etiology, immunology Saccades / physiology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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