Document Detail

Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection.
MedLine Citation:
PMID:  17404319     Owner:  NLM     Status:  MEDLINE    
IL-7 promotes survival of resting T lymphocytes and induces T cell proliferation in lymphopenic conditions. As elevated IL-7 levels occur in HIV-infected individuals in addition to high Fas expression on T cells and increased sensitivity to Fas-induced apoptosis, we analyzed whether IL-7 has a regulatory role in Fas-mediated T cell apoptosis. We show that IL-7 up-regulates Fas expression on naive and memory T cells through a mechanism that involves translocation of Fas molecules from intracellular compartments to the cell membrane. IL-7 induced the association of Fas with the cytoskeletal component ezrin and a polarized Fas expression on the cell surface. The potential role of IL-7 in Fas up-regulation in vivo was verified in IL-7-treated macaques and in HIV-infected or chemotherapy treated patients by the correlation between serum IL-7 levels and Fas expression on T cells. IL-7 treatment primed T cells for Fas-induced apoptosis in vitro and serum IL-7 levels correlated with the sensitivity of T cells to Fas-induced apoptosis in HIV-infected individuals. Our data suggest an important role for IL-7 in Fas-mediated regulation of T cell homeostasis. Elevated IL-7 levels associated with lymphopenic conditions, including HIV-infection, might participate in the increased sensitivity of T cells for activation-induced apoptosis.
Caroline Fluur; Angelo De Milito; Terry J Fry; Nancy Vivar; Liv Eidsmo; Ann Atlas; Cristina Federici; Paola Matarrese; Mariantonia Logozzi; Eva Rajnavölgyi; Crystal L Mackall; Stefano Fais; Francesca Chiodi; Bence Rethi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  178     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-03     Completed Date:  2007-05-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5340-50     Citation Subset:  AIM; IM    
Department of Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Antigens, CD95 / physiology*
Cell Polarity
HIV Infections / drug therapy,  immunology*
Immunologic Memory
Interleukin-7 / blood,  pharmacology*
Lymphocyte Activation
Macaca fascicularis
Receptors, Interleukin-7 / analysis
T-Lymphocytes / physiology*
Reg. No./Substance:
0/Antigens, CD95; 0/Interleukin-7; 0/Receptors, Interleukin-7

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