| Potential role of Borreria hispida in ameliorating cardiovascular risk factors. | |
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MedLine Citation:
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PMID: 19455054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Borreria hispida (BHE), a weed of Rubiaceae family, is being used from time immemorial as an alternative therapy for diabetes. To evaluate the scientific background of using BHE as therapy to reduce cardiovascular risk, a group of rats were given BHE for a period of 30 days, whereas control animals were given the vehicle only. The animals were sacrificed, the hearts were isolated, and perfused with buffer. All the hearts were subjected to 30-minute ischemia followed by 2-hour reperfusion. Compared with vehicle-treated rats, BHE-treated rat hearts showed improved post-ischemic ventricular function and exhibited reduced myocardial infarct size and cardiomyocyte apoptosis. The level of cytochrome c expression and caspase 3 activation was also reduced. BHE elevated antiapoptotic proteins Bcl-2 and heme oxygenase-1 and stimulated the phosphorylation of survival protein Akt simultaneously decreasing the apoptotic proteins Bax and Src. In addition, BHE enhanced the protein expression of peroxisome proliferator-activated receptor-gamma, peroxisome proliferator-activated receptor-delta, and Glut-4, probably revealing the antiobese and antidiabetic potential of BHE. These results indicate that treatment with BHE improves cardiac function and ameliorates various risk factors associated with cardiac disease, suggesting that BHE can be considered as a potential plant-based nutraceutical and pharmaceutical agent for the management of cardiovascular diseases. |
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Authors:
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Hannah R Vasanthi; Subhendu Mukherjee; Istvan Lekli; Diptarka Ray; Gayathri Veeraraghavan; Dipak K Das |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 53 ISSN: 1533-4023 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 499-506 Citation Subset: IM |
Affiliation:
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Herbal and Indian Medicine Research Laboratory, Department of Biochemistry, Sri Ramachandra University, Chennai, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Cell Survival / drug effects Heart / drug effects*, physiopathology Heme Oxygenase-1 / metabolism Male Myocardial Reperfusion Injury / drug therapy*, metabolism, pathology, physiopathology Myocardium / metabolism, pathology* PPAR delta / metabolism PPAR gamma / metabolism Phosphorylation Plant Components, Aerial / chemistry Plant Extracts / chemistry, pharmacology*, therapeutic use Rats Rats, Sprague-Dawley Risk Factors Rubiaceae / chemistry* Signal Transduction bcl-2-Associated X Protein / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL 22559/HL/NHLBI NIH HHS; HL 33889/HL/NHLBI NIH HHS; HL 34360/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/PPAR delta; 0/PPAR gamma; 0/Plant Extracts; 0/bcl-2-Associated X Protein; EC 1.14.99.3/Heme Oxygenase-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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