Document Detail

Potential risk of light and room temperature exposure to preimplantation embryos.
MedLine Citation:
PMID:  3203758     Owner:  NLM     Status:  MEDLINE    
Adverse effects of simultaneous exposure to visible light and room temperature were investigated in rabbit early cleavage stages and morulae. Routine laboratory conditions were mimicked as close as possible. Embryonic development was assessed by cell proliferation via incorporation of tritiated thymidine, by gross morphology, and by electron microscopy. Damage was detectable in both stages at 1-hour exposure by statistically significant impaired cell proliferation. Compared with single exposure to each individual stressor, combined exposure to light and room temperature amplified detrimental effects. Ultrastructural analysis of light-exposed cleavage stages revealed no indication of cell injury at 4-hour exposure. Gross morphology proved to be too inaccurate to evaluate damage imposed by exposure toward both physical factors investigated.
B Fischer; A Schumacher; C Hegele-Hartung; H M Beier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  50     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-30     Completed Date:  1989-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  938-44     Citation Subset:  IM    
Department of Anatomy and Reproductive Biology, Medical Faculty, RWTH Aachen, West Germany.
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MeSH Terms
Blastocyst / physiology*,  ultrastructure
Risk Factors
Thymidine / metabolism
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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