| Potential for pulmonary protection by nebulized milrinone during warm ischemia. | |
| | |
MedLine Citation:
|
PMID: 19100384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: A method to compensate for the donor shortage may be the utilization of donation after cardiac death. The control of lung injury against warm ischemia is crucial in manipulating donors after cardiac death. Nebulization is a simple and feasible drug delivery route after cardiac death. Herein we have examined the potential effect of nebulized milrinone, a phosphodiesterase III inhibitor, on pulmonary warm ischemia. MATERIALS AND METHODS: Deeply anesthetized rats were euthanized by exsanguination. Lungs were exposed to warm ischemia with ventilation up to 2 hours. Milrinone was nebulized for 10 minutes at the beginning of warm ischemia (n = 5). In the control group (n = 5), normal saline was nebulized for the same time. At given intervals, the lungs were partially resected to measure adenine nucleotide and cyclic adenosine monophosphate levels. RESULTS: In both groups, lung tissue cyclic adenosine monophosphate levels decreased significantly at 2 hours after warm ischemia; however, there was no significant difference between the groups. Lung tissue adenosine triphosphate levels significantly decreased at 2 hours after ischemia in the control group, while they did not drop up to 2 hours in the milrinone group. Further, lung tissue adenosine triphosphate levels at 2 hours after ischemia were higher in the milrinone group than the control group. CONCLUSIONS: Our results confirmed that milrinone nebulization during warm ischemia maintained lung tissue adenosine triphosphate levels. Therefore, milrinone nebulization may have potential for lung protection against warm ischemia. |
| | |
Authors:
|
F Chen; J Zhang; A Aoyama; T Okamoto; T Fujinaga; T Bando |
Related Documents
:
|
8321634 - Acidosis slows the response of oxidative phosphorylation to metabolic demand in isolate... 856754 - Comparative efficacy of coronary vasodilatory methods. 2632814 - 31p nmr spectroscopy of hypertrophied rat heart: effect of graded global ischemia. 1372344 - Drug-induced changes in blood pressure lead to changes in extracellular concentrations ... 22585944 - Renal sympathetic denervation suppresses postapneic blood pressure rises and atrial fib... 2840394 - The renin response to aortic occlusion is enhanced by stimulation of the hypothalamus. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Transplantation proceedings Volume: 40 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-12-22 Completed Date: 2009-02-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
|
Languages: eng Pagination: 3335-8 Citation Subset: IM |
Affiliation:
|
Department of Organ Preservation Technology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenine Nucleotides
/
metabolism Animals Cyclic AMP / metabolism Ischemia / prevention & control* Lung / drug effects, physiology* Male Milrinone / administration & dosage, therapeutic use Phosphodiesterase Inhibitors / administration & dosage, therapeutic use Pulmonary Circulation / drug effects, physiology Rats Rats, Inbred Lew Reperfusion Injury / prevention & control* Vasodilator Agents / administration & dosage, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Adenine Nucleotides; 0/Phosphodiesterase Inhibitors; 0/Vasodilator Agents; 60-92-4/Cyclic AMP; 78415-72-2/Milrinone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hepatic ischemia-reperfusion induces insulin resistance via down-regulation during the early steps i...
Next Document: Intestinal ischemia/reperfusion injury triggers activation of innate toll-like receptor 4 and adapti...