Document Detail


Potential for pulmonary protection by nebulized milrinone during warm ischemia.
MedLine Citation:
PMID:  19100384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A method to compensate for the donor shortage may be the utilization of donation after cardiac death. The control of lung injury against warm ischemia is crucial in manipulating donors after cardiac death. Nebulization is a simple and feasible drug delivery route after cardiac death. Herein we have examined the potential effect of nebulized milrinone, a phosphodiesterase III inhibitor, on pulmonary warm ischemia. MATERIALS AND METHODS: Deeply anesthetized rats were euthanized by exsanguination. Lungs were exposed to warm ischemia with ventilation up to 2 hours. Milrinone was nebulized for 10 minutes at the beginning of warm ischemia (n = 5). In the control group (n = 5), normal saline was nebulized for the same time. At given intervals, the lungs were partially resected to measure adenine nucleotide and cyclic adenosine monophosphate levels. RESULTS: In both groups, lung tissue cyclic adenosine monophosphate levels decreased significantly at 2 hours after warm ischemia; however, there was no significant difference between the groups. Lung tissue adenosine triphosphate levels significantly decreased at 2 hours after ischemia in the control group, while they did not drop up to 2 hours in the milrinone group. Further, lung tissue adenosine triphosphate levels at 2 hours after ischemia were higher in the milrinone group than the control group. CONCLUSIONS: Our results confirmed that milrinone nebulization during warm ischemia maintained lung tissue adenosine triphosphate levels. Therefore, milrinone nebulization may have potential for lung protection against warm ischemia.
Authors:
F Chen; J Zhang; A Aoyama; T Okamoto; T Fujinaga; T Bando
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  40     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3335-8     Citation Subset:  IM    
Affiliation:
Department of Organ Preservation Technology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenine Nucleotides / metabolism
Animals
Cyclic AMP / metabolism
Ischemia / prevention & control*
Lung / drug effects,  physiology*
Male
Milrinone / administration & dosage,  therapeutic use
Phosphodiesterase Inhibitors / administration & dosage,  therapeutic use
Pulmonary Circulation / drug effects,  physiology
Rats
Rats, Inbred Lew
Reperfusion Injury / prevention & control*
Vasodilator Agents / administration & dosage,  therapeutic use
Chemical
Reg. No./Substance:
0/Adenine Nucleotides; 0/Phosphodiesterase Inhibitors; 0/Vasodilator Agents; 60-92-4/Cyclic AMP; 78415-72-2/Milrinone

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