Document Detail

Potential for pulmonary protection by nebulized milrinone during warm ischemia.
MedLine Citation:
PMID:  19100384     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A method to compensate for the donor shortage may be the utilization of donation after cardiac death. The control of lung injury against warm ischemia is crucial in manipulating donors after cardiac death. Nebulization is a simple and feasible drug delivery route after cardiac death. Herein we have examined the potential effect of nebulized milrinone, a phosphodiesterase III inhibitor, on pulmonary warm ischemia. MATERIALS AND METHODS: Deeply anesthetized rats were euthanized by exsanguination. Lungs were exposed to warm ischemia with ventilation up to 2 hours. Milrinone was nebulized for 10 minutes at the beginning of warm ischemia (n = 5). In the control group (n = 5), normal saline was nebulized for the same time. At given intervals, the lungs were partially resected to measure adenine nucleotide and cyclic adenosine monophosphate levels. RESULTS: In both groups, lung tissue cyclic adenosine monophosphate levels decreased significantly at 2 hours after warm ischemia; however, there was no significant difference between the groups. Lung tissue adenosine triphosphate levels significantly decreased at 2 hours after ischemia in the control group, while they did not drop up to 2 hours in the milrinone group. Further, lung tissue adenosine triphosphate levels at 2 hours after ischemia were higher in the milrinone group than the control group. CONCLUSIONS: Our results confirmed that milrinone nebulization during warm ischemia maintained lung tissue adenosine triphosphate levels. Therefore, milrinone nebulization may have potential for lung protection against warm ischemia.
F Chen; J Zhang; A Aoyama; T Okamoto; T Fujinaga; T Bando
Related Documents :
23829504 - Late presentation of a case of high pressure cement injection injury to the hand.
2757434 - Enhanced myocardial protection with adenosine.
2158384 - Relation between the o2 supply:demand ratio, mvo2, and adenosine formation in hearts st...
9631984 - Caffeine abstinence augments the systolic blood pressure response to adenosine in humans.
23692624 - Effect of cuff type on arterial occlusion.
2676954 - Diaphragmatic plate electrode stimulation of the hamster diaphragm.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  40     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3335-8     Citation Subset:  IM    
Department of Organ Preservation Technology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenine Nucleotides / metabolism
Cyclic AMP / metabolism
Ischemia / prevention & control*
Lung / drug effects,  physiology*
Milrinone / administration & dosage,  therapeutic use
Phosphodiesterase Inhibitors / administration & dosage,  therapeutic use
Pulmonary Circulation / drug effects,  physiology
Rats, Inbred Lew
Reperfusion Injury / prevention & control*
Vasodilator Agents / administration & dosage,  therapeutic use
Reg. No./Substance:
0/Adenine Nucleotides; 0/Phosphodiesterase Inhibitors; 0/Vasodilator Agents; 60-92-4/Cyclic AMP; 78415-72-2/Milrinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hepatic ischemia-reperfusion induces insulin resistance via down-regulation during the early steps i...
Next Document:  Intestinal ischemia/reperfusion injury triggers activation of innate toll-like receptor 4 and adapti...