Document Detail


Potential protection of skin by acute UVA irradiation--from cellular to animal models.
MedLine Citation:
PMID:  16620921     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The UVA (320-380 nm) component of sunlight has oxidizing properties which may be deleterious to skin cells and tissue but can also lead to the strong up-regulation of the heme-catabolizing enzyme, heme oxygenase-1. This enzyme has well-established antioxidant actions in cells as well as anti-inflammatory properties in mammals. There is also evidence from rodent models that this enzyme is responsible for the UVA-mediated protection against UVB-induced immunosuppression that occurs in skin. The relevance of these findings to acute and chronic effects of sunlight including skin carcinogenesis is currently under investigation as are the potential implications for sunlight protection in humans.
Authors:
R M Tyrrell; V E Reeve
Publication Detail:
Type:  Journal Article; Review     Date:  2006-02-28
Journal Detail:
Title:  Progress in biophysics and molecular biology     Volume:  92     ISSN:  0079-6107     ISO Abbreviation:  Prog. Biophys. Mol. Biol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401233     Medline TA:  Prog Biophys Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  86-91     Citation Subset:  IM    
Affiliation:
Department of Pharmacy and Pharmacology University of Bath, BA2 7AY, UK. R.M.Tyrrell@bath.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Heme Oxygenase-1 / immunology*
Humans
Immunosuppression / methods
Mice
Models, Animal
Oxidative Stress / immunology*,  radiation effects
Radiation Dosage
Skin / immunology*,  radiation effects*
Skin Diseases / immunology*,  prevention & control*
Ultraviolet Rays*
Chemical
Reg. No./Substance:
EC 1.14.99.3/Heme Oxygenase-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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