| Potential programming of dopaminergic circuits by early life stress. | |
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MedLine Citation:
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PMID: 21088961 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Stress and high levels of glucocorticoids during pre- and early postnatal life seem to alter developmental programs that assure dopaminergic transmission in the mesolimbic, mesocortical, and nigrostriatal systems. The induced changes are likely to be determined by the ontogenetic state of development of these brain regions at the time of stress exposure and their stability is associated with increased lifetime susceptibility to psychiatric disorders, including drug addiction. This article is intended to serve as a starting point for future studies aimed at the attenuation or reversal of the effects of adverse early life events on dopamine-regulated behaviors. |
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Authors:
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Ana-João Rodrigues; Pedro Leão; Miguel Carvalho; Osborne F X Almeida; Nuno Sousa |
Publication Detail:
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Type: Journal Article Date: 2010-11-19 |
Journal Detail:
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Title: Psychopharmacology Volume: 214 ISSN: 1432-2072 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 107-20 Citation Subset: IM |
Affiliation:
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Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057, Braga, Portugal. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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