Document Detail

Potential predictive biomarkers of obesity in Burmese cats.
MedLine Citation:
PMID:  22840209     Owner:  NLM     Status:  Publisher    
Australian Burmese cats are predisposed to diabetes mellitus and, compared to other breeds, have delayed triglyceride clearance that may result in subtle changes within cells and tissues that trigger specific alterations in gene expression within peripheral blood leucocytes (PBLs). Expression of genes involved in energy metabolism (glucose-6-phosphate dehydrogenase and malate dehydrogenase), lipogenesis (ATP citrate lyase [ACL], fatty acid synthase [FAS] and sterol regulatory binding protein-1c [SREBP-1c]), and insulin signalling (insulin receptor substrates 1 and 2, and phosphatidylinositol-3 kinase), as well as cholesterol lipoprotein subfraction profiling were carried out on PBLs from lean Burmese cats and compared with similar profiles of age and gender matched lean and obese Australian domestic shorthaired cats (DSHs) in an attempt to identify possible biomarkers for assessing obesity. For the majority of the genes examined, the lean Burmese cats demonstrated similar PBL gene expression patterns as age and gender matched obese Australian DSH cats. Lean Burmese had increased expression of ACL and FAS, but not SREBP-1c, a main upstream regulator of lipid synthesis, suggesting possible aberrations in lipogenesis. Moreover, lean Burmese displayed a 3- to 4-fold increase in the very low density cholesterol fraction percentage, which was double that for obese DSH cats, indicating an increased degree of lipid dysregulation especially in relation to triglycerides. The findings suggest that Burmese cats may have a particular propensity for dysregulation in lipid metabolism.
Peter Lee; Akihiro Mori; Marcia Coradini; Nobuko Mori; Fumi Sagara; Ichiro Yamamoto; Jacquie S Rand; Toshiro Arai
Related Documents :
15763519 - Molecular cloning and seasonal expression of oyster glycogen phosphorylase and glycogen...
16324119 - Rhythms in clock proteins in the mouse pars tuberalis depend on mt1 melatonin receptor ...
16096739 - Atypical patterns of circadian clock gene expression in human peripheral blood mononucl...
8809759 - Circadian expression of genes involved in the purine biosynthetic pathway of the cyanob...
22318949 - Hypothalamic fkbp51 is induced by fasting, and elevated hypothalamic expression promote...
12916719 - Oscillation of human period 1 (hper1) reporter gene activity in human neuroblastoma cel...
25182489 - Bicarbonate increases binding affinity of vibrio cholerae toxt to virulence gene promot...
24634239 - Gene expression profiling of duchenne muscular dystrophy reveals characteristics along ...
22343189 - Transplantation of the gal regulon into g-protein signaling circuitry in yeast.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-25
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  -     ISSN:  1532-2971     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Veterinary Science, School of Veterinary Medicine, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Molecular and histological evidence of brown adipose tissue in adult cats.
Next Document:  Retrospective comparison of prednisolone and ursodeoxycholic acid for the treatment of feline lympho...