Document Detail

Potential pathophysiological mechanisms in osteonecrosis of the jaw.
MedLine Citation:
PMID:  21291478     Owner:  NLM     Status:  Publisher    
Bisphosphonates are used in the treatment of hypercalcemia of malignancy, skeletal complications associated with metastastic bone disease, Paget's disease, and osteoporosis. Osteonecrosis of the jaw (ONJ) is a recently described clinical condition that has been associated with the use of nitrogen-containing bisphosphonates. Reports describing this entity first appeared in the literature in 2003. While there have been significant numbers of case reports and a limited number of retrospective and prospective studies examining risk factors associated with ONJ, the pathophysiology of this condition remains elusive. In this review, we explore proposed mechanisms underlying ONJ development and identify potential areas for future investigation.
Regina Landesberg; Victoria Woo; Serge Cremers; Matthew Cozin; Darja Marolt; Gordana Vunjak-Novakovic; Stavroula Kousteni; Srikala Raghavan
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Publication Detail:
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1218     ISSN:  1749-6632     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  62-79     Citation Subset:  -    
Copyright Information:
© 2011 New York Academy of Sciences.
University of Connecticut Health Center, Division of Oral and Maxillofacial Surgery, School of Dental Medicine, Farmington, Connecticut. Department of Biomedical Sciences, School of Dental Medicine, University of Nevada Las Vegas, Las Vegas, Nevada. Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, New York. College of Dental Medicine, Columbia University, New York, New York. Department of Biomedical Engineering, Columbia University, New York, New York. Division of Oral and Maxillofacial Surgery, College of Physicians and Surgeons, Department of Dermatology, College of Dental Medicine, Columbia University, New York, New York.
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