Document Detail


Potential neural progenitor cells in fetal liver and regenerating liver.
MedLine Citation:
PMID:  19002859     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
From unfractionated embryonic mice liver cells, appreciable amount of spherical bodies containing nestin-positive cells were generated in the presence of neuronal growth factors. Following cultivation on poly-D: -lysine/laminin-coated slips, approximately 70% of the cells expressed neuronal markers, and 16% had long processes. Functional analysis of these long-process-bearing cells with the whole-cell patch clamp method showed an inward current in response to glutamate, GABA, and serotonin as the neuronal characteristics. Furthermore, regenerating liver in adult mice also contained nestin-positive cells to the same extent as fetal liver. Regenerating liver could have potential as a source of neural cells for autologous transplantation.
Authors:
Fuminari Komatsu; Imre Farkas; Hiroyasu Akatsu; Kiyohide Kojima; Takeo Fukushima; Hidechika Okada
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Publication Detail:
Type:  Journal Article     Date:  2008-06-05
Journal Detail:
Title:  Cytotechnology     Volume:  56     ISSN:  0920-9069     ISO Abbreviation:  Cytotechnology     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807027     Medline TA:  Cytotechnology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  209-17     Citation Subset:  -    
Affiliation:
Choju Medical Institute, Fukushimura Hospital, Noyori-cho, Toyohashi, 441-8124, Japan, fkomatsu@fukuoka-u.ac.jp.
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