Document Detail

Potential for milk containing penicillin G or amoxicillin to cause residues in calves.
MedLine Citation:
PMID:  11210024     Owner:  NLM     Status:  MEDLINE    
The potential for antibiotic residues in calves from consuming milk containing penicillin G or amoxicillin was investigated. Six calves were fed milk replacer, 6% body weight twice daily, containing 0.293, 2.92, or 5.85 microg of penicillin/ml (ppm) G or 0.25, 1.0, or 2.0 microg of amoxicillin/ml for three consecutive feedings. Urine and blood samples were collected after each feeding. Serum and urine samples were tested with a microbial receptor assay and a microbial growth inhibition assay to indicate potential drug residues. Penicillin G and amoxicillin were detected in the serum and urine of several calves 3 h after drinking spiked milk replacer. Possible violative drug residues in the calves were detected by the microbial growth inhibition assay up to 15 h after drinking spiked milk replacer. Penicillin G, but not amoxicillin, could be detected in urine 24 h after the final feeding of spiked milk replacer. Subsequently, six calves were fed milk replacer containing 11.7 microg of penicillin G/ml (ppm) twice daily, 6% body weight per feeding. Calves were slaughtered 3 h after the final feeding. Mean (+/-SD) concentrations of penicillin G measured by high-pressure liquid chromatography in liver, kidney, muscle, and serum were 0.409 (+/-0.167) microg/g, 0.031 (+/-0.012) microg/g 0.008 (+/-0.002) microg/g, and 0.013 (+/-0.006) mg/ml, respectively. This study indicates that calves fed milk with amoxicillin or penicillin G could possibly have violative residues if slaughtered within 24 h after feeding. Violative drug residues in liver tissue were found in calves slaughtered 3 h after consuming milk replacer containing 11.7 microg of penicillin G/ml (ppm).
J M Musser; K L Anderson; J E Rushing; W A Moats
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dairy science     Volume:  84     ISSN:  0022-0302     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-07     Completed Date:  2001-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  126-33     Citation Subset:  IM    
Department of Farm Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
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MeSH Terms
Amoxicillin / analysis*
Animal Feed* / analysis
Cattle / metabolism*
Chromatography, High Pressure Liquid
Drug Residues
Kidney / chemistry
Liver / chemistry
Metabolic Clearance Rate
Milk* / chemistry
Muscles / chemistry
Penicillin G / analysis*
Reg. No./Substance:
26787-78-0/Amoxicillin; 61-33-6/Penicillin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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