Document Detail

Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children.
MedLine Citation:
PMID:  20624647     Owner:  NLM     Status:  MEDLINE    
Epidemiologic data suggest that the incidence of food allergy (FA) is increasing among children, yet a satisfactory model of its pathogenesis remains elusive. FA is the consequence of maladaptive immune responses to common and otherwise innocuous food antigens. Concurrent with the increase in FA is an epidemic of vitamin D deficiency (VDD) caused by several factors, especially decreased sunlight/UVB exposure. There is growing appreciation of the importance of the pleiotropic hormone vitamin D in the development of tolerance, immune system defenses, and epithelial barrier integrity. We propose a "multiple-hit" model in which VDD in a developmentally critical period increases susceptibility to colonization with abnormal intestinal microbial flora and gastrointestinal infections, contributing to abnormal intestinal barrier permeability and excess and inappropriate exposure of the immune system to dietary allergens. A compounding effect (and additional "hit") of VDD is the promotion of a pro-sensitization immune imbalance that might compromise immunologic tolerance and contribute to FA. We propose that early correction of VDD might promote mucosal immunity, healthy microbial ecology, and allergen tolerance and thereby blunt the FA epidemic in children.
Milo F Vassallo; Carlos A Camargo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-07-10
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  126     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-06     Completed Date:  2010-09-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA.
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MeSH Terms
Allergens / immunology,  metabolism
Child, Preschool
Epithelium / immunology,  metabolism,  physiopathology
Food Hypersensitivity* / epidemiology,  immunology,  metabolism,  physiopathology
Gastrointestinal Diseases / epidemiology,  immunology,  metabolism,  physiopathology
Immune Tolerance / immunology,  radiation effects
Immunity, Mucosal / immunology,  radiation effects
Models, Theoretical
Ultraviolet Rays
Vitamin D / immunology*,  metabolism
Vitamin D Deficiency* / epidemiology,  immunology,  metabolism,  physiopathology
Grant Support
Reg. No./Substance:
0/Allergens; 1406-16-2/Vitamin D

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