| Potential mechanisms of hypocholesterolaemic effect of Thai spices/dietary extracts. | |
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MedLine Citation:
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PMID: 20623425 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Several Thai spices/dietary ingredients were previously shown to have hypocholesterolaemic effects. These studies were mostly conducted in animal models in which the mechanisms of action were not yet well-established. Therefore, this study aimed to investigate the potential mechanism of hypocholesterolaemic action of 12 selected plants, namely Hibiscus sabdariffa L., Moringa oleifera Lam., Cucurbita moschata Duchesne, Ananas comosus (L.) Merr., Zingiber officinale, Morus alba L., Camellia sinensis (L.) Kuntze, Piper nigrum L., Alpinia galanga (L.) Willd., Curcuma zedoaria Rose, Bacopa monnieri (L.) Wettst. and Piper retrofractum Vahl., widely used as spices and ingredients in various types of Thai food. The extract of P. nigrum at 100 µg mL(-1) was found to be the most effective cholesterol uptake inhibitor whereas those of A. galanga and C. sinensis effectively inhibited pancreatic lipase activity with IC(50) values of 8.99 ± 3.41 and 12.36 ± 1.23 µg mL(-1), respectively. The potency of extracts from H. sabdariffa, M. oleifera and C. moschata at 100 µg mL(-1) were found to be similar to 0.4 µg mL(-1) pravastatin in inhibiting HMG-CoA reductase and possibly reduced cholesterol biosynthesis. This study also demonstrated that several of the tested plants possessed multiple sites of action that were possibly responsible for their cholesterol-lowering effect in the in vivo model. |
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Authors:
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Acharaporn Duangjai; Kornkanok Ingkaninan; Nanteetip Limpeanchob |
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Publication Detail:
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Type: Journal Article Date: 2010-07-08 |
Journal Detail:
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Title: Natural product research Volume: 25 ISSN: 1478-6427 ISO Abbreviation: Nat. Prod. Res. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167924 Medline TA: Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 341-52 Citation Subset: IM |
Affiliation:
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Department of Pharmacy Practice and Center of Excellence for Innovation in Chemistry, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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