| Potential marker of oral squamous cell carcinoma aggressiveness detected by fluorescence in situ hybridization in fine-needle aspiration biopsies. | |
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MedLine Citation:
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PMID: 12412169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Amplification of chromosome 11q13 is a frequent event in carcinogenesis of the head and neck squamous cell carcinomas including oral carcinoma. METHODS: Fluorescence in situ hybridization (FISH), using a BAC clone specific for the cyclin D1 gene (CCND1), was performed on specimens obtained by fine-needle aspiration biopsy (FNAB) from 50 patients with primary oral squamous cell carcinomas (OSCCs.). RESULTS: The CCND1 numerical aberration was identified in 21 (42.0%) of 50 patients with primary OSCCs. The CCND1 amplification was determined in 16 (32.0%) of these patients. Immunohistochemical staining revealed that all 21 tumors showing the CCND1 numerical aberration overexpressed the CCND1 protein. The CCND1 numerical aberration was associated significantly with histopathologic grading (P = 0.032), the mode of invasion (P = 0.047), the presence of cancer cells at the resection margin (P = 0.033), pathologic lymph nodestatus (P = 0.045), disease recurrence (P = 0.004), and survival (P = 0.004). The disease-free and overall survival period of patients with the CCND1 numerical aberration was significantly shorter than that of patients without the CCND1 numerical aberration (P = 0.0016 and P = 0.0019, respectively). Moreover, a multivariate analysis showed that the CCND1 numerical aberration retained an independent prognostic value. CONCLUSIONS: The CCND1 numerical aberration is useful both as a prognostic indicator that is independent of the TNM classification, and an indicator to assist in determination of the appropriate treatment for patients with OSCCs. Analysis of the CCND1 numerical aberration using FISH on FNABs may be a useful and practical method for predicting aggressive tumors, recurrence, and clinical outcome in patients with OSCCs. |
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Authors:
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Ryozo Miyamoto; Narikazu Uzawa; Shunya Nagaoka; Koichi Nakakuki; Yasushi Hirata; Teruo Amagasa |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer Volume: 95 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-04 Completed Date: 2003-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 2152-9 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2002 American Cancer Society. |
Affiliation:
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Department of Maxillofacial Surgery, Maxillofacial Reconstruction and Function, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. ryou-m.mfs@tmd.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Biopsy, Needle Carcinoma, Squamous Cell / genetics, pathology*, surgery Cyclin D1 / analysis, genetics* Disease-Free Survival Female Humans In Situ Hybridization, Fluorescence Male Middle Aged Mouth Neoplasms / genetics, pathology*, surgery Neoplasm Recurrence, Local Prognosis Survival Analysis Tumor Markers, Biological / analysis, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; 136601-57-5/Cyclin D1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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