| Potential interactions of drug-natural health products and natural health products-natural health products among children. | |
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MedLine Citation:
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PMID: 18346508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the frequency of concurrent use of conventional medications and natural health products (NHP) and their potential interactions in children arriving at an emergency department. STUDY DESIGN: A survey of parents and patients 0 to 18 years at a large pediatric ED in Toronto, Ontario, Canada. RESULTS: A total of 1804 families were interviewed in this study. Concurrent drug-NHP use was documented in 355 (20%) of patients and 269 (15%) of NHP users were receiving more than one NHP simultaneously. Theoretically possible NHP-drug or NHP-NHP interactions in the preceding 3 months were identified in 285 (16%) children. There were 35 different NHP-medication interaction pairs and 41 NHP-NHP interaction pairs. NHP-medication interactions were predominantly pharmacokinetic (modified absorption, 35%); potential NHP-NHP interactions were mostly pharmacodynamic (increased risk of bleeding, 47%). CONCLUSIONS: Medications are used concurrently with NHP in every fifth pediatric patient in the emergency department and many NHP users are receiving more than 1 NHP simultaneously. One quarter of all paired medication-NHP or NHP-NHP could potentially cause interactions. Although we can not confirm that these were true interactions resulting in clinical symptoms, parents and health care providers need to balance the potential benefit of concurrent NHP-medication use with its potential harms. |
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Authors:
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Ran D Goldman; Alex L Rogovik; David Lai; Sunita Vohra |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-07 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 152 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-18 Completed Date: 2008-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 521-6, 526.e1-4 Citation Subset: AIM; IM |
Affiliation:
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Pediatric Research in Emergency Therapeutics Program, Division of Pediatric Emergency Medicine, BC Children's Hospital, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia. rgoldman@cw.bc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biological Products / therapeutic use* Canada Child Child, Preschool Drug Interactions* Drug Therapy / utilization Drug Therapy, Combination Female Health Care Surveys Herb-Drug Interactions* Humans Infant Male Pharmaceutical Preparations* / adverse effects Phytotherapy* / utilization Vitamins / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Pharmaceutical Preparations; 0/Vitamins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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