Document Detail


Potential impact of parental Tdap immunization on infant pertussis hospitalizations.
MedLine Citation:
PMID:  22749592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We estimated the potential impact of parental Tdap immunization before delivery, at delivery and at the 2-week newborn visit on U.S. infant pertussis hospitalizations. We used published data for pertussis hospitalization rates among U.S. infants aged 0-4 months, the Tdap vaccine efficacy in adults, and the proportion of infants with pertussis <6 months of age in which either parent was the source (16-40% from mothers and 16-20% from fathers). Immunizing parents before pregnancy or ≥ 2 weeks prior to delivery should reduce pertussis hospitalizations among infants 0-4 months by 2694-9314 if both parents are vaccinated, and by 1347-6909 if only mothers are vaccinated. Greater reductions in pertussis hospitalizations would be achieved if parents are immunized ≥ 2 weeks prior to delivery than after delivery or the 2-week newborn visit. Although immunizing parents prior to pregnancy or delivery is best, immunizing parents in the postpartum period should provide protection to that newborn and to infants of subsequent pregnancies.
Authors:
Timothy R Peters; Gretchen C Banks; Beverly M Snively; Katherine A Poehling
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-27
Journal Detail:
Title:  Vaccine     Volume:  30     ISSN:  1873-2518     ISO Abbreviation:  Vaccine     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-27     Completed Date:  2013-04-25     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  5527-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
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MeSH Terms
Descriptor/Qualifier:
Diphtheria-Tetanus-acellular Pertussis Vaccines / administration & dosage*,  immunology
Female
Hospitalization / statistics & numerical data*
Humans
Immunization Programs / statistics & numerical data*
Immunization Schedule
Infant
Infant, Newborn
Male
Parents
Postpartum Period
Pregnancy
Program Evaluation
United States
Whooping Cough / prevention & control*
Grant Support
ID/Acronym/Agency:
K23 AI065805/AI/NIAID NIH HHS; K23AI65805/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Diphtheria-Tetanus-acellular Pertussis Vaccines
Comments/Corrections

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