| Potential impact of (68)Ga-DOTATOC PET/CT on stereotactic radiotherapy planning of meningiomas. | |
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MedLine Citation:
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PMID: 19763565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Since meningiomas show a high expression of somatostatin receptor subtype 2, PET with (68)Ga-DOTATOC was proposed as an additional imaging modality beside CT and MRI for planning radiotherapy. We investigated the input of (68)Ga-DOTATOC-PET/CT on the definition of the "gross tumour volume" (GTV) in meningiomas, in order to assess the potential value of this method. METHODS: Prior to radiotherapy, 42 patients with meningiomas (26 f, 16 m, mean age 55) underwent MRI and (68)Ga-DOTATOC-PET/CT examinations. History: operated n = 24, radiotherapy n = 1, operation and radiotherapy n = 8, no treatment n = 9. PET/CT and MRI data were co-registered using a BrainLAB workstation. For comparison, the GTV was defined first under consideration of CT and MRI data, then using PET data. RESULTS: 3/42 patients were excluded from the analysis (two with negative PET results, one with an extensive tumour, not precisely delineable by MRI or PET/CT). The average GTV(CT/MRI) was 22(+/-19)cm(3); GTV(PET) was 23(+/-20)cm(3). Additional GTV, obtained as a result of PET was 9(+/-10)cm(3) and was observed in patients with osseous infiltration. In some pre-treated patients there were intratumoural areas (as identified in CT/MRI) without SR-expression (7(+/-11)cm(3)). Common GTV as obtained by both CT/MRI and PET was 15(+/-14)cm(3). The mean bi-directional difference between the GTV(CT/MRI) and GTV(PET) accounted to 16(+/-15)cm(3) (93%, p < 0.001). In a subgroup of seven patients with multiple meningiomas, PET showed a total of 19 lesions; nine of them were not recognizable by CT or MRI. CONCLUSION: (68)Ga-DOTATOC-PET enables delineation of SR-positive meningiomas and delivers additional information to both CT and MRI regarding the planning of stereotactic radiotherapy. The acquisition on a PET/CT scanner helps to estimate the relation of PET findings to anatomical structures and is especially useful for detection of osseous infiltration. (68)Ga-DOTATOC-PET also allows detection of additional lesions in patients with multiple meningiomas. |
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Authors:
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Fonyuy Nyuyki; Michail Plotkin; Reinhold Graf; Roger Michel; Ingo Steffen; Timm Denecke; Lilli Geworski; Daniel Fahdt; Winfried Brenner; Reinhard Wurm |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-09-18 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 37 ISSN: 1619-7089 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 310-8 Citation Subset: IM |
Affiliation:
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Department for Nuclear Medicine, Charit?-Universit?tsmedizin Berlin, Charit?platz 1, 10117, Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Feasibility Studies Humans Meningioma / radionuclide imaging*, surgery* Middle Aged Octreotide / analogs & derivatives*, diagnostic use Organometallic Compounds / diagnostic use* Positron-Emission Tomography / methods* Preoperative Care / methods Prognosis Radiopharmaceuticals / diagnostic use Radiosurgery / methods* Reproducibility of Results Sensitivity and Specificity Subtraction Technique Surgery, Computer-Assisted / methods Tomography, X-Ray Computed / methods* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Ga(III)-DOTATOC; 0/Organometallic Compounds; 0/Radiopharmaceuticals; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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