Document Detail


Potential impact of (68)Ga-DOTATOC PET/CT on stereotactic radiotherapy planning of meningiomas.
MedLine Citation:
PMID:  19763565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Since meningiomas show a high expression of somatostatin receptor subtype 2, PET with (68)Ga-DOTATOC was proposed as an additional imaging modality beside CT and MRI for planning radiotherapy. We investigated the input of (68)Ga-DOTATOC-PET/CT on the definition of the "gross tumour volume" (GTV) in meningiomas, in order to assess the potential value of this method.
METHODS: Prior to radiotherapy, 42 patients with meningiomas (26 f, 16 m, mean age 55) underwent MRI and (68)Ga-DOTATOC-PET/CT examinations.
HISTORY: operated n = 24, radiotherapy n = 1, operation and radiotherapy n = 8, no treatment n = 9. PET/CT and MRI data were co-registered using a BrainLAB workstation. For comparison, the GTV was defined first under consideration of CT and MRI data, then using PET data.
RESULTS: 3/42 patients were excluded from the analysis (two with negative PET results, one with an extensive tumour, not precisely delineable by MRI or PET/CT). The average GTV(CT/MRI) was 22(+/-19)cm(3); GTV(PET) was 23(+/-20)cm(3). Additional GTV, obtained as a result of PET was 9(+/-10)cm(3) and was observed in patients with osseous infiltration. In some pre-treated patients there were intratumoural areas (as identified in CT/MRI) without SR-expression (7(+/-11)cm(3)). Common GTV as obtained by both CT/MRI and PET was 15(+/-14)cm(3). The mean bi-directional difference between the GTV(CT/MRI) and GTV(PET) accounted to 16(+/-15)cm(3) (93%, p < 0.001). In a subgroup of seven patients with multiple meningiomas, PET showed a total of 19 lesions; nine of them were not recognizable by CT or MRI.
CONCLUSION: (68)Ga-DOTATOC-PET enables delineation of SR-positive meningiomas and delivers additional information to both CT and MRI regarding the planning of stereotactic radiotherapy. The acquisition on a PET/CT scanner helps to estimate the relation of PET findings to anatomical structures and is especially useful for detection of osseous infiltration. (68)Ga-DOTATOC-PET also allows detection of additional lesions in patients with multiple meningiomas.
Authors:
Fonyuy Nyuyki; Michail Plotkin; Reinhold Graf; Roger Michel; Ingo Steffen; Timm Denecke; Lilli Geworski; Daniel Fahdt; Winfried Brenner; Reinhard Wurm
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-09-18
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  37     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-05-06     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  310-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Feasibility Studies
Humans
Meningioma / radionuclide imaging*,  surgery*
Middle Aged
Octreotide / analogs & derivatives*,  diagnostic use
Organometallic Compounds / diagnostic use*
Positron-Emission Tomography / methods*
Preoperative Care / methods
Prognosis
Radiopharmaceuticals / diagnostic use
Radiosurgery / methods*
Reproducibility of Results
Sensitivity and Specificity
Subtraction Technique
Surgery, Computer-Assisted / methods
Tomography, X-Ray Computed / methods*
Young Adult
Chemical
Reg. No./Substance:
0/Ga(III)-DOTATOC; 0/Organometallic Compounds; 0/Radiopharmaceuticals; RWM8CCW8GP/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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