Document Detail


Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis.
MedLine Citation:
PMID:  18769381     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prevention of neonatal infection-related mortality represents a significant global challenge particularly in the vulnerable premature population. The increased risk of death from sepsis is likely due to the specific immune deficits found in the neonate as compared to the adult. Stimulation of the neonatal immune system to prevent and/or treat infection has been attempted in the past largely without success. In this review, we identify some of the known deficits in the neonatal immune system and their clinical impact, summarize previous attempts at immunomodulation and the outcomes of these interventions, and discuss the potential of novel immunomodulatory therapies to improve neonatal sepsis outcome.
Authors:
J L Wynn; J Neu; L L Moldawer; O Levy
Publication Detail:
Type:  Journal Article; Review     Date:  2008-09-04
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  29     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-29     Completed Date:  2009-06-11     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-88     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Immunologic Factors / therapeutic use*
Infant, Newborn
Male
Probiotics / therapeutic use
Risk Factors
Sepsis / drug therapy*,  immunology,  prevention & control*
Grant Support
ID/Acronym/Agency:
R01 GM040586/GM/NIGMS NIH HHS; R01 GM097531/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Immunologic Factors
Comments/Corrections
Erratum In:
J Perinatol. 2009 Jul;29(7):527

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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