Document Detail

Potential hippocampal region atrophy in diabetes mellitus type 2: a voxel-based morphometry VSRAD study.
MedLine Citation:
PMID:  20512543     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Among diabetes mellitus type 2 (DM2) patients, the frequency of cognitive dysfunction is higher and the relative risk of Alzheimer's disease (AD) is approximately twice that of nondiabetics. Cognitive impairment symptoms of AD are induced by limbic system dysfunction, and an early-stage AD brain without dementia has the potential for atrophy in the hippocampal region. In this study, we estimated potential hippocampal region atrophy in DM2 and pursued the association between DM2 and cognitive impairment/AD. MATERIALS AND METHODS: Voxel-based morphometry analysis was performed in 28 diabetics (14 men, 14 women; ages 59-79 years, mean 70.7 years) and 28 sex- and agematched (+/-1 year) nondiabetics. Severity of gray matter loss in the hippocampal region and whole brain were investigated. Group analysis was performed using twotailed unpaired t-test; significance was assumed with less than 1% (P < 0.01) of the critical rate. RESULTS: There was a significant difference between diabetics and nondiabetics regarding the severity of hippocampal region atrophy and whole-brain atrophy. Only diabetics showed a positive correlation for severity of hippocampal region atrophy and whole-brain atrophy (rs = 0.69, P < 0.0001). CONCLUSION: Aged DM2 patients have the potential for hippocampal region atrophy, and its dysfunction can be related to the expression of a cognitive impairment that resembles AD.
Kazutoshi Kamiyama; Akihiko Wada; Masaki Sugihara; Souichi Kurioka; Kumi Hayashi; Takafumi Hayashi; Takeshi Yoshisako; Nobuko Yamamoto; Youji Tsuchie; Syuhei Yamaguchi; Toshitsugu Sugimoto; Hajime Kitagaki
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Publication Detail:
Type:  Journal Article     Date:  2010-05-29
Journal Detail:
Title:  Japanese journal of radiology     Volume:  28     ISSN:  1867-108X     ISO Abbreviation:  Jpn J Radiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101490689     Medline TA:  Jpn J Radiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  266-72     Citation Subset:  IM    
Department of Radiology, Ohda Municipal Hospital, Ohda, Japan.
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MeSH Terms
Alzheimer Disease / pathology*
Atrophy / pathology
Case-Control Studies
Cognition Disorders / pathology*
Diabetes Mellitus, Type 2 / pathology*
Hippocampus / pathology*
Image Interpretation, Computer-Assisted
Imaging, Three-Dimensional
Magnetic Resonance Imaging*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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