Document Detail

Potential functions of plasma prorenin; regional activation and tissue extraction.
MedLine Citation:
PMID:  3308199     Owner:  NLM     Status:  MEDLINE    
The fate of circulating inactive prorenin was examined in patients and volunteers. Prorenin was activated either by acid-dialysis with warming at pH 3.3 or with trypsin. The results were similar but omission of warming reduced the value by 13%. In 6 volunteers, 20 min forearm venous occlusion raised regional total (T) and inactive (I) plasma renin concentration (PRC) by 51% and 48% without change of active (A) renin. During intense forearm exercise the ratio APRC: IPRC did not change in muscle or skin venous blood. Body anaerobic exercise increased APRC 3.7-fold without change in IPRC. These procedures activate plasminogen but are without effect on prorenin. In 18 patient with stable angina, TPRC was lower in coronary sinus than arterial blood (p less than 0.001) but APRC was not affected. A-V differences were not detected across the leg. Prorenin is apparently stable in the circulation but extracted by the heart.
R L Thatcher; J S Butty; J A Whitworth; V D Hunt; P F Shaw; S L Skinner; J D Horowitz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  9     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-17     Completed Date:  1987-11-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1415-34     Citation Subset:  IM    
Department of Nephrology, Royal Melbourne Hospital, Australia.
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MeSH Terms
Angina Pectoris / blood
Coronary Vessels
Enzyme Activation
Enzyme Precursors / blood*,  isolation & purification
Hot Temperature
Isometric Contraction
Leg / blood supply
Middle Aged
Physical Exertion
Protein Processing, Post-Translational
Renin / biosynthesis,  blood*,  isolation & purification
Reg. No./Substance:
0/Enzyme Precursors; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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