Document Detail


Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat.
MedLine Citation:
PMID:  1676659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A model for predicting the magnitude of error (% Err) in measuring tissue concentrations of a compound that have not been corrected for residual blood in the tissue was previously developed. The model was tested using data for phencyclidine tissue distribution in the rat. It is shown that % Err may be expressed as a function of volume fraction of blood in tissue (VF)B and tissue-to-blood distribution coefficient. Correction for residual blood is important when the volume fraction of the blood in the tissue is large and when the compound is not taken up substantially by the tissue. On the other hand, a correction may not be necessary when (VF)B is small and uptake of the compound into the tissue is substantial.
Authors:
S P Khor; H Bozigian; M Mayersohn
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug metabolism and disposition: the biological fate of chemicals     Volume:  19     ISSN:  0090-9556     ISO Abbreviation:  Drug Metab. Dispos.     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-08-14     Completed Date:  1991-08-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421550     Medline TA:  Drug Metab Dispos     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  486-90     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona, Tucson 85721.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromium Radioisotopes / diagnostic use
Male
Models, Biological*
Pharmacokinetics*
Phencyclidine / blood,  pharmacokinetics*
Rats
Rats, Inbred F344
Grant Support
ID/Acronym/Agency:
DA02680/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Chromium Radioisotopes; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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