Document Detail

Potential effects of chocolate on human pregnancy: a randomized controlled trial.
MedLine Citation:
PMID:  22537244     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This trial was undertaken to evaluate the effects of high-cocoa-content chocolate supplementation in pregnancy on several haematochemical and clinical parameters. The study had as reference population the pregnant women requesting an obstetric control at Outpatient Clinic of Obstetrics and Gynaecology of the S. Maria della Misericordia University Hospital, Perugia, Italy. Candidates who participated in this study were all Caucasian women aged 18-40 years, who had a single gestation pregnancy between 11th + 0 and 13th + 0 week gestational age.
METHODS: We conducted a single-center randomized controlled trial. The pregnant women selected were randomized into Group A, which received daily doses of 30 g of chocolate (70% cocoa), and Group B, which was free to increase their diet with other foods.
RESULTS: Ninety women were randomized. Significant difference was found between the two groups for diastolic blood pressure (p = 0.05), systolic (p < 0.0001) and levels of liver enzymes, with values lower in Group A than in Group B. Total cholesterol levels and weight gain in Group A did not increase more than in Group B.
CONCLUSIONS: A modest daily intake of high-cocoa-content chocolate contributes to reduce blood pressure, glycemic and liver pattern during pregnancy without affecting the weight gain.
Gian Carlo Di Renzo; Eleonora Brillo; Maila Romanelli; Giuseppina Porcaro; Federica Capanna; Tomi T Kanninen; Sandro Gerli; Graziano Clerici
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-06-05
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-18     Completed Date:  2013-03-17     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1860-7     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Blood Glucose / metabolism
Blood Pressure
Cholesterol / blood
Diet Surveys
Glucose Tolerance Test
Liver / enzymology
Prenatal Nutritional Physiological Phenomena*
Prospective Studies
Single-Blind Method
Weight Gain
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 97C5T2UQ7J/Cholesterol
Comment In:
Pract Midwife. 2014 Feb;17(2):38-41   [PMID:  24600832 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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