Document Detail


Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity.
MedLine Citation:
PMID:  12505434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper investigates the possible link between non-workplace cadmium (Cd) exposure, cytochrome P450 expression and hypertension. We present results of our investigation into the relationships between liver and kidney Cd burdens and the abundance of the CYP isoform 4A11. Our data show associations between non-workplace Cd exposure and changes in the abundance of hepatic and renal cortical CYP4A11. In liver the levels of immunochemically detectable CYP4A11 were positively correlated with tissue Cd content while in contrast CYP4A11 abundance was inversely correlated with kidney Cd burden. These differences are most likely related to the different Cd burden of the tissues. These observations suggest the potential for involvement of Cd as a mediator of CYP4A11 expression in kidney cortex and indicate that elevations in kidney Cd content may be involved in hypertension via alteration of the expression of this particular isoform. Potential mechanisms by which Cd may alter CYP4A11 expression are discussed briefly.
Authors:
Jason R Baker; Soisungwan Satarug; Robert J Edwards; Michael R Moore; David J Williams; Paul E B Reilly
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  137     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-30     Completed Date:  2003-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  85-93     Citation Subset:  IM    
Affiliation:
National Research Center for Environmental Toxicology, University of Queensland, 39 Kessels Road, Coopers Plains, Qld. 4108, Brisbane, Australia. s374705@student.uq.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Body Burden
Cadmium / adverse effects*,  pharmacokinetics
Cadmium Poisoning / enzymology*
Child
Child, Preschool
Cytochrome P-450 Enzyme System / metabolism*
Environmental Exposure*
Female
Humans
Hypertension* / enzymology,  etiology
Kidney Cortex / drug effects,  enzymology
Liver / metabolism
Male
Microsomes, Liver / drug effects,  enzymology
Middle Aged
Chemical
Reg. No./Substance:
7440-43-9/Cadmium; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.15.3/CYP4A11 protein, human

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