Document Detail


Potential of diffusion tensor MR imaging in the assessment of cognitive impairments in children with periventricular leukomalacia born preterm.
MedLine Citation:
PMID:  23084875     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate MR diffusion tensor imaging (DTI) and fiber tractography (FT) in the assessment of altered major white matter fibers correlated with cognitive functions in preterm infants with periventricular leukomalacia (PVL), to explore the neural foundation for PVL children's cognitive impairments.
MATERIALS AND METHODS: Forty six preterm infants (16 ± 4.7 months) suffered from PVL and 16 age-matched normal controls were recruited. Developmental quotient (DQ) was recorded to evaluate PVL children's cognitive functions. According to the DQ scores, patients were divided into three groups: mild, moderate and severe cognitive impairment groups. DTI scan was performed. Fractional anisotropy (FA) values of major white matter fibers were measured and their correlation with cognitive levels was evaluated.
RESULTS: Compared with the control group, the PVL group showed a significant mean FA reduction in bilateral corticospinal tract (CST), anterior/posterior limb of internal capsule (ICAL/ICPL), arcuate fasciculus (AF), corona radiate (CR), superior longitudinal fasciculus (SLF), splenium of corpus callosum (SCC) (p<0.05) and bilateral posterior thalamic radiation (PTR) (p<0.01). The FA values of left CST, bilateral AF, anterior cingulum (ACG), SLF, ICAL, ICPL, PTR, CR, genu of corpus callosum (GCC), SCC and middle cerebellar peduncle showed significant negative correlations with the cognitive levels.
CONCLUSIONS: DTI can provide more information for understanding the pathophysiology of cognitive impairment in preterm infants with PVL.
Authors:
Shanshan Wang; Guoguang Fan; Ke Xu; Ci Wang
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Publication Detail:
Type:  Journal Article     Date:  2012-10-22
Journal Detail:
Title:  European journal of radiology     Volume:  82     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-07-09     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  158-64     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2012. Published by Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Cognition Disorders / etiology,  pathology*
Diffusion Magnetic Resonance Imaging / methods*
Feasibility Studies
Female
Humans
Infant, Newborn
Infant, Premature
Leukomalacia, Periventricular / complications*,  pathology*
Male
Reproducibility of Results
Sensitivity and Specificity
Comments/Corrections
Comment In:
Rofo. 2013 Nov;185(11):1031-2   [PMID:  24308052 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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