Document Detail

Potential dietary exposure to p-nonylphenol from food-contact use of tris(nonylphenyl)phosphite (TNPP).
MedLine Citation:
PMID:  11665731     Owner:  NLM     Status:  MEDLINE    
The potential exposure to p-nonylphenol from the use of tris(nonylphenyl)phosphite (TNPP) in food-contact materials was calculated. The calculation was made on the basis of migration data from moulded plaques prepared from linear low-density polyethylene (LLDPE), films prepared from LLDPE and polyvinyl chloride (PVC) films. The data were obtained using the customary expermental procedures developed by the US Food and Drug Administration (FDA). The potential migration of p-nonylphenol to food from the use of TNPP as a component of food-contact articles was determined using food-simulating solvents and time and temperature conditions recommended by the FDA. Using the data obtained from these studies, along with procedures based on the FDA's conventional method for estimating potential dietary exposure using food simulating migration data, the potential dietary exposure to p-nonylphenol from the use of TNPP was determined to be approximately 25.5 parts per billion (ppb). Because the conditions of the migration tests exaggerate actual use conditions, this value overstates the potential dietary exposure.
S R Howe; P Surana; M R Jakupca; L Borodinsky
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food additives and contaminants     Volume:  18     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-22     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  England    
Other Details:
Languages:  eng     Pagination:  1021-39     Citation Subset:  IM    
Worker and Product Safety, The Society of the Plastics Industry, Inc., Washington, DC 20006-1301, USA.
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MeSH Terms
Chromatography, High Pressure Liquid
Food Contamination*
Food Packaging*
Phenols / pharmacokinetics*
Polyethylenes / chemistry
Polyvinyl Chloride / chemistry
Reg. No./Substance:
0/Phenols; 0/Polyethylenes; 25154-52-3/nonylphenol; 9002-86-2/Polyvinyl Chloride

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