| Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice. | |
| | |
MedLine Citation:
|
PMID: 20171261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Soy and soy-based products are widely consumed by infants and adult individuals. There has been speculation that the presence of isoflavone phytoestrogens in soybean cause adverse effects on the development and function of the male reproductive system. The purpose of this study was to examine the influence of dietary soy and phytoestrogens on testicular and reproductive functions. Male mice were fed from conception to adulthood with either a high soy-containing diet or a soy-free diet. Although adult mice fed a soy-rich diet exhibited normal male behaviour and were fertile, we observed a reduced proportion of haploid germ cells in testes correlating with a 25% decrease in epididymal sperm counts and a 21% reduction in litter size. LH and androgens levels were not affected but transcripts coding for androgen-response genes in Sertoli cells and Gapd-s, a germ cell-specific gene involved in sperm glycolysis and mobility were significantly reduced. In addition, we found that dietary soy decreased the size of the seminal vesicle but without affecting its proteolytic activity. Taken together, these studies show that long-term exposure to dietary soy and phytoestrogens may affect male reproductive function resulting in a small decrease in sperm count and fertility. |
| | |
Authors:
|
Christopher R Cederroth; Celine Zimmermann; Jean-Louis Beny; Olivier Schaad; Chantal Combepine; Patrick Descombes; Daniel R Doerge; François P Pralong; Jean-Dominique Vassalli; Serge Nef |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-18 |
Journal Detail:
|
Title: Molecular and cellular endocrinology Volume: 321 ISSN: 1872-8057 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-04-12 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 152-60 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blotting, Western Diet* Fertility / physiology* Flow Cytometry Hormones / blood Isoflavones / blood Male Mice Microarray Analysis Phytoestrogens / metabolism* Reverse Transcriptase Polymerase Chain Reaction Soybeans / metabolism* Sperm Count |
| Chemical | |
Reg. No./Substance:
|
0/Hormones; 0/Isoflavones; 0/Phytoestrogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Melanin-concentrating Hormone Facilitates Migration of Preadipocytes.
Next Document: PLC/CAMK IV-NF-kappaB involved in the receptor for advanced glycation end products mediated signalin...