Document Detail

Potential control of gastroesophageal reflux by local modulation of transient lower esophageal sphincter relaxations.
MedLine Citation:
PMID:  11749948     Owner:  NLM     Status:  MEDLINE    
Transient lower esophageal sphincter relaxations (TLESRs) are neurally mediated abrupt reductions in lower esophageal sphincter (LES) pressure. TLESRs are not usually associated with deglutition or secondary peristalsis but are thought to be necessary for venting swallowed air from the stomach. Their central role in acid reflux, however, makes them a compelling therapeutic target for patients with gastroesophageal reflux disease. Pharmacologic approaches for reducing TLESR frequency are being studied, but theoretically more promising are endoscopic approaches that interfere with mechanoreceptor function. Further study into the mechanisms of action of these approaches is needed, as are controlled clinical trials to define the true utility of these techniques and identify patients who will receive the most benefit.
B T Massey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  111 Suppl 8A     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-25     Completed Date:  2002-01-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186S-189S     Citation Subset:  AIM; IM    
Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.
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MeSH Terms
Esophagogastric Junction / drug effects,  physiopathology*
Esophagoscopy / methods*
Gastroesophageal Reflux / diagnosis,  therapy*
Muscle Relaxation / drug effects
Parasympatholytics / therapeutic use*
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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