Document Detail

Potential confounding factors in measurement of exhaled nitric oxide.
MedLine Citation:
PMID:  17072050     Owner:  NLM     Status:  MEDLINE    
Nitric oxide is present in the exhaled air. Factors affecting the level of exhaled nitric oxide (exNO), except for smoking, are not well defined. In this study we seek to determine whether age, gender, body mass index (BMI), part of the day, or time after a meal could modulate exNO levels. exNO was examined by the use of a chemiluminescence method in 100 subjects - 31 women (19 nonsmokers and 12 smokers) and 69 males (55 nonsmokers and 14 smokers). Forty four subjects took medications due to stable coronary disease, 22 were after heart transplantation, and 34 did not take any drugs. We found that exNO levels did not differ either between the whole groups of women and men or between smokers and nonsmokers of either respective group (4.91 +/-2.38 vs. 6.27 +/-4.23 ppb; 3.21 +/-1.16 vs. 3.71 +/-1.55 ppb; 5.98 +/-2.35 vs. 6.92 +/-4.45 ppb). The correlation of exNO with age in the whole population was weak (r=0.23; P=0.02) and insignificant in the smoking and nonsmoking subgroups. Likewise, correlations of exNO with BMI, part of the day, or time after a meal were insignificant in whole population as well as the subgroups. We conclude that the aforementioned factors are not able to confound the measurement of exNO in the population studied.
P Nadziakiewicz; P Knapik; P Rozentryt; D Ziora; S Dworniczak; J Kozielski; L Poloński
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  57 Suppl 4     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-12-19     Revised Date:  2008-05-19    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  IM    
Department of Cardiac Anesthesia, Silesian Center for Heart Diseases, Zabrze, Poland.
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MeSH Terms
Breath Tests*
Confounding Factors (Epidemiology)
Middle Aged
Nitric Oxide / metabolism*
Smoking / metabolism
Reg. No./Substance:
10102-43-9/Nitric Oxide

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