Document Detail


Potential biomarkers in the urine of myocardial infarction rats: a metabolomic method and its application.
MedLine Citation:
PMID:  21152560     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A metabolomic method using reversed-phase liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) was developed to obtain a systematic view of the development and progression of myocardial infarction (MI). By combining with partial least squares discriminant analysis (PLS-DA), 16 biomarkers in rat urine were identified and eight of them were related to the pathway of energy metabolism. Among the regulated pathways, the citric acid cycle related network was acutely perturbed. The metabolomic results not only supplied a systematic view of the development and progression of MI but also provided the theoretical basis for the prevention or treatment of MI. The developed method was also used to analyze the therapeutic effects of a traditional Chinese medicine (TCM) named Shexiang Baoxin Pill (SBP), a widely used anti-MI medicine in clinics. The results showed that SBP administration could provide satisfactory effects on MI through partially regulating the perturbed pathway of energy metabolism.
Authors:
Peng Jiang; Weixing Dai; Shikai Yan; Zhongliang Chen; Ruilin Xu; Jianmi Ding; Li Xiang; Shuping Wang; Runhui Liu; Weidong Zhang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-10
Journal Detail:
Title:  Molecular bioSystems     Volume:  7     ISSN:  1742-2051     ISO Abbreviation:  Mol Biosyst     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-15     Completed Date:  2011-08-01     Revised Date:  2011-11-08    
Medline Journal Info:
Nlm Unique ID:  101251620     Medline TA:  Mol Biosyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  824-31     Citation Subset:  IM    
Affiliation:
School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, P.R. China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / metabolism,  urine*
Chromatography, Reverse-Phase
Disease Models, Animal
Drugs, Chinese Herbal / administration & dosage,  therapeutic use
Energy Metabolism
Least-Squares Analysis
Male
Mass Spectrometry
Metabolomics
Myocardial Infarction / drug therapy,  metabolism,  urine*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Drugs, Chinese Herbal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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