| Potential biomarkers in the urine of myocardial infarction rats: a metabolomic method and its application. | |
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MedLine Citation:
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PMID: 21152560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A metabolomic method using reversed-phase liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) was developed to obtain a systematic view of the development and progression of myocardial infarction (MI). By combining with partial least squares discriminant analysis (PLS-DA), 16 biomarkers in rat urine were identified and eight of them were related to the pathway of energy metabolism. Among the regulated pathways, the citric acid cycle related network was acutely perturbed. The metabolomic results not only supplied a systematic view of the development and progression of MI but also provided the theoretical basis for the prevention or treatment of MI. The developed method was also used to analyze the therapeutic effects of a traditional Chinese medicine (TCM) named Shexiang Baoxin Pill (SBP), a widely used anti-MI medicine in clinics. The results showed that SBP administration could provide satisfactory effects on MI through partially regulating the perturbed pathway of energy metabolism. |
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Authors:
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Peng Jiang; Weixing Dai; Shikai Yan; Zhongliang Chen; Ruilin Xu; Jianmi Ding; Li Xiang; Shuping Wang; Runhui Liu; Weidong Zhang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-12-10 |
Journal Detail:
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Title: Molecular bioSystems Volume: 7 ISSN: 1742-2051 ISO Abbreviation: Mol Biosyst Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-15 Completed Date: 2011-08-01 Revised Date: 2011-11-08 |
Medline Journal Info:
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Nlm Unique ID: 101251620 Medline TA: Mol Biosyst Country: England |
Other Details:
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Languages: eng Pagination: 824-31 Citation Subset: IM |
Affiliation:
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School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, P.R. China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / metabolism, urine* Chromatography, Reverse-Phase Disease Models, Animal Drugs, Chinese Herbal / administration & dosage, therapeutic use Energy Metabolism Least-Squares Analysis Male Mass Spectrometry Metabolomics Myocardial Infarction / drug therapy, metabolism, urine* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Drugs, Chinese Herbal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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