Document Detail


Potential biomarkers for detecting pulmonary arterial hypertension in patients with systemic sclerosis.
MedLine Citation:
PMID:  19116719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary arterial hypertension (PAH) is the major complication of systemic sclerosis (SSc) and the main cause of morbi-mortality. It is important to find predictors for this vascular problem. The objective of this study was to determine the serum levels of different biomarkers in patients with SSc and secondary PAH and to compare them with those of healthy control subjects to define their potential role as predictors of PAH. Cross-section study in which 20 patients with SSc were included. PAH was diagnosed by echocardiogram. The optical densities of endoglin (Eng), endothelin-1 (ET-1), platelet-derived growth factor (PDGF), tumoral necrosis factor alpha (TNF-alpha), Transforming growth factor beta 2 (TGF-beta2) and Interleukin 8 (IL-8) were measured in 20 patients with SSc and 20 healthy controls matched by sex. The differences found between the group of patients with PAH and the control group were (mean or median and range): ET-1 (0.20; 0.10-0.35 vs. 0.16; 0.10-0.24; P = 0.0276), IL-8 (195.7; 45.5-504 vs. 118.9; 23-299.5; P = 0.0364), TNF-alpha (0.70; 0.50-0.96 vs. 0.48; 0.38-0.65; P = 1 x 10(-8)) and Eng (0.95; 0.57-1.72 vs. 0.75; 0.57-0.89; P = 0.0028). A correlation was found between the progression of the disease and the development of Raynaud's phenomenon (Rho: 0.67 and P = 0.0011), ET-1 and Eng (Rho: 0.53 and P = 0.0196), and between IL-8 and Eng (Rho: 0.68 and P = 0.0019). In conclusions, the elevation of the serum levels of Eng and ET-1 could represent a useful tool as PAH biomarkers. Nevertheless, the diagnostic value of these markers needs to be determined by prospective studies.
Authors:
Paola Coral-Alvarado; Gerardo Quintana; Maria Fernanda Garces; Libia Alexandra Cepeda; Jorge Eduardo Caminos; Federico Rondon; Antonio Iglesias-Gamarra; Jose Felix Restrepo
Related Documents :
1395099 - Evaluation of serum levels of tumour necrosis factor-alpha (tnf-alpha) and soluble il-2...
20955949 - Inflammatory cytokines in saliva: early signs of metabolic disorders in chronic kidney ...
18849599 - Proinflammatory cytokine profiles of patients with elderly-onset rheumatoid arthritis: ...
8785169 - Interleukin-6 (il-6) in patients with behçet's disease.
19578629 - Increased levels of il-10, il-12, and ifn- in patients with visceral leishmaniasis.
12694249 - Mediators of inflammation correlate with microalbuminuria in patients with non-hodgkin'...
10582809 - Evaluation of transmyocardial laser revascularization (tmlr) by gated myocardial perfus...
23199589 - Taliglucerase alfa leads to favorable bone marrow responses in patients with type i gau...
18726939 - Clean intermittent self-catheterization: a burden for the patient?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-31
Journal Detail:
Title:  Rheumatology international     Volume:  29     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-04     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1017-24     Citation Subset:  IM    
Affiliation:
Rheumatology Unit, Universidad Nacional de Colombia, Carrera 30 calle 45, Bogotá, Colombia. pxcoral@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Antigens, CD / diagnostic use*
Biological Markers / blood
Case-Control Studies
Cross-Sectional Studies
Echocardiography / adverse effects
Endothelin-1 / diagnostic use*
Female
Humans
Hypertension, Pulmonary / diagnosis*,  etiology,  physiopathology
Male
Receptors, Cell Surface
Scleroderma, Systemic / complications*,  diagnosis*,  physiopathology
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Biological Markers; 0/ENG protein, human; 0/Endothelin-1; 0/Receptors, Cell Surface

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lung parenchymal consolidation as an uncommon presentation and cause of delayed diagnosis in atypica...
Next Document:  Functional characterization of a stilbene synthase gene using a transient expression system in plant...