Document Detail

Potential biomarkers for detecting pulmonary arterial hypertension in patients with systemic sclerosis.
MedLine Citation:
PMID:  19116719     Owner:  NLM     Status:  MEDLINE    
Pulmonary arterial hypertension (PAH) is the major complication of systemic sclerosis (SSc) and the main cause of morbi-mortality. It is important to find predictors for this vascular problem. The objective of this study was to determine the serum levels of different biomarkers in patients with SSc and secondary PAH and to compare them with those of healthy control subjects to define their potential role as predictors of PAH. Cross-section study in which 20 patients with SSc were included. PAH was diagnosed by echocardiogram. The optical densities of endoglin (Eng), endothelin-1 (ET-1), platelet-derived growth factor (PDGF), tumoral necrosis factor alpha (TNF-alpha), Transforming growth factor beta 2 (TGF-beta2) and Interleukin 8 (IL-8) were measured in 20 patients with SSc and 20 healthy controls matched by sex. The differences found between the group of patients with PAH and the control group were (mean or median and range): ET-1 (0.20; 0.10-0.35 vs. 0.16; 0.10-0.24; P = 0.0276), IL-8 (195.7; 45.5-504 vs. 118.9; 23-299.5; P = 0.0364), TNF-alpha (0.70; 0.50-0.96 vs. 0.48; 0.38-0.65; P = 1 x 10(-8)) and Eng (0.95; 0.57-1.72 vs. 0.75; 0.57-0.89; P = 0.0028). A correlation was found between the progression of the disease and the development of Raynaud's phenomenon (Rho: 0.67 and P = 0.0011), ET-1 and Eng (Rho: 0.53 and P = 0.0196), and between IL-8 and Eng (Rho: 0.68 and P = 0.0019). In conclusions, the elevation of the serum levels of Eng and ET-1 could represent a useful tool as PAH biomarkers. Nevertheless, the diagnostic value of these markers needs to be determined by prospective studies.
Paola Coral-Alvarado; Gerardo Quintana; Maria Fernanda Garces; Libia Alexandra Cepeda; Jorge Eduardo Caminos; Federico Rondon; Antonio Iglesias-Gamarra; Jose Felix Restrepo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-31
Journal Detail:
Title:  Rheumatology international     Volume:  29     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-04     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1017-24     Citation Subset:  IM    
Rheumatology Unit, Universidad Nacional de Colombia, Carrera 30 calle 45, Bogotá, Colombia.
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MeSH Terms
Age of Onset
Antigens, CD / diagnostic use*
Biological Markers / blood
Case-Control Studies
Cross-Sectional Studies
Echocardiography / adverse effects
Endothelin-1 / diagnostic use*
Hypertension, Pulmonary / diagnosis*,  etiology,  physiopathology
Receptors, Cell Surface
Scleroderma, Systemic / complications*,  diagnosis*,  physiopathology
Reg. No./Substance:
0/Antigens, CD; 0/Biological Markers; 0/ENG protein, human; 0/Endothelin-1; 0/Receptors, Cell Surface

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