Document Detail

Potential atrial arrhythmogenicity of adipocytes: implications for the genesis of atrial fibrillation.
MedLine Citation:
PMID:  20149554     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation is the most common sustained cardiac arrhythmia. Obesity and metabolic syndrome are independent risk factors for atrial fibrillation, and epicardial adipose tissues are highly associated with the genesis of atrial fibrillation, compared to visceral fat. Adipocytes can produce inflammatory cytokines and adipocytokines, which may enhance inflammation and oxidative stress in patients with obesity or metabolic syndrome. Moreover, it is possible that local interactions between epicardial adipose tissue and the adjacent myocardium can directly produce electrical or structural remodelings in the atrium. Taken together, we hypothesized that epicardial adipocytes contain distinctive arrhythmogenicity through increases in inflammatory cytokines, adipocytokines, and adipocyte-cardiomyocyte interactions to induce atrial fibrillation.
Yung-Kuo Lin; Yi-Jen Chen; Shih-Ann Chen
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Publication Detail:
Type:  Journal Article     Date:  2010-02-09
Journal Detail:
Title:  Medical hypotheses     Volume:  74     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1026-9     Citation Subset:  IM    
Cardiovascular Center, Far Eastern Memorial Hospital, Taipei, Taiwan.
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MeSH Terms
Adipocytes / physiology*
Adipokines / physiology
Atrial Fibrillation / etiology*,  physiopathology
Electrophysiological Phenomena
Inflammation Mediators / physiology
Metabolic Syndrome X / complications
Models, Cardiovascular
Myocytes, Cardiac / physiology
Obesity / complications
Pericardium / physiopathology
Risk Factors
Reg. No./Substance:
0/Adipokines; 0/Inflammation Mediators

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