| Potential association of Helicobacter cinaedi with atrial arrhythmia and atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 22309125 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Helicobacter cinaedi is being increasingly recognized as an emerging pathogen. Reports of recurrent bacteremia and isolation of H. cinaedi organisms from a patient with myopericarditis led us to hypothesize that H. cinaedi may be associated with chronic inflammatory cardiovascular diseases such as atrial arrhythmia and atherosclerosis. To assess the association of H. cinaedi with atrial arrhythmia, we performed a retrospective case-control study of patients at Kumamoto University Hospital from 2005 to 2008. The arrhythmia status of these patients was determined by using electrocardiography and electrophysiological study. Multiple logistic regression analysis was used to identify independent risk factors. In a comparison of case patients (n= 132) with control subjects (n= 137), H. cinaedi seropositivity was identified as an independent risk factor for atrial arrhythmia (odds ratio, 5.13; 95% confidence interval, 3.0-8.7; P < 0.001). There were no significant differences, however, between these two groups with respect to anti-Helicobacter pylori IgG level, anti-Chlamydophila pneumoniae IgG level, and other studied variables. IgG levels against H. cinaedi and H. pylori, however, showed an inverse correlation, which suggests cross-immunity between these two bacteria. Also, to explore the association of H. cinaedi with atherosclerosis, we performed an immunohistochemical analysis of atherosclerotic aortic tissues collected post mortem from nine patients. Immunohistochemistry of atherosclerotic aortic tissues from all nine patients successfully detected H. cinaedi antigens inside CD68(+) macrophages. These findings provide the first evidence, to our knowledge, of the potential association of H. cinaedi with atrial arrhythmia and atherosclerosis. |
| | |
Authors:
|
Shahzada Khan; Tatsuya Okamoto; Koji Enomoto; Naomi Sakashita; Kohta Oyama; Shigemoto Fujii; Tomohiro Sawa; Motohiro Takeya; Hisao Ogawa; Hiroshige Yamabe; Takaaki Akaike |
Related Documents
:
|
21991485 - Autoantibodies to the β(1)-adrenoceptor from patients with periodontitis as a risk fac... 21694465 - Analysis of gp73 in patients with hcc as a function of anti-cancer treatment. 18394965 - The specificity and sensitivity of transcranial ultrasound in the differential diagnosi... 20694845 - Clinical features associated with rem sleep behavior disorder symptoms in the early sta... 6847375 - Gastric carcinoids and atrophic gastritis. evidence for an association. 12049545 - Outcomes of laparoscopic nissen fundoplication in patients with the "hypercontractile e... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-7 |
Journal Detail:
|
Title: Microbiology and immunology Volume: - ISSN: 1348-0421 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7703966 Medline TA: Microbiol Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Societies and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Department of Microbiology, Department of Cardiovascular Medicine, Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan, and Department of Cardiac Arrhythmias, Kumamoto University Hospital, Kumamoto 860-8556, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effects of varying alcohol concentrations commonly found in mouth rinses on the force decay of e...
Next Document: Lipase-Catalyzed Production of Pinolenic Acid Concentrate from Pine Nut Oil Using a Recirculating Pa...