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Potential association of Helicobacter cinaedi with atrial arrhythmia and atherosclerosis.
MedLine Citation:
PMID:  22309125     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Helicobacter cinaedi is being increasingly recognized as an emerging pathogen. Reports of recurrent bacteremia and isolation of H. cinaedi organisms from a patient with myopericarditis led us to hypothesize that H. cinaedi may be associated with chronic inflammatory cardiovascular diseases such as atrial arrhythmia and atherosclerosis. To assess the association of H. cinaedi with atrial arrhythmia, we performed a retrospective case-control study of patients at Kumamoto University Hospital from 2005 to 2008. The arrhythmia status of these patients was determined by using electrocardiography and electrophysiological study. Multiple logistic regression analysis was used to identify independent risk factors. In a comparison of case patients (n= 132) with control subjects (n= 137), H. cinaedi seropositivity was identified as an independent risk factor for atrial arrhythmia (odds ratio, 5.13; 95% confidence interval, 3.0-8.7; P < 0.001). There were no significant differences, however, between these two groups with respect to anti-Helicobacter pylori IgG level, anti-Chlamydophila pneumoniae IgG level, and other studied variables. IgG levels against H. cinaedi and H. pylori, however, showed an inverse correlation, which suggests cross-immunity between these two bacteria. Also, to explore the association of H. cinaedi with atherosclerosis, we performed an immunohistochemical analysis of atherosclerotic aortic tissues collected post mortem from nine patients. Immunohistochemistry of atherosclerotic aortic tissues from all nine patients successfully detected H. cinaedi antigens inside CD68(+) macrophages. These findings provide the first evidence, to our knowledge, of the potential association of H. cinaedi with atrial arrhythmia and atherosclerosis.
Authors:
Shahzada Khan; Tatsuya Okamoto; Koji Enomoto; Naomi Sakashita; Kohta Oyama; Shigemoto Fujii; Tomohiro Sawa; Motohiro Takeya; Hisao Ogawa; Hiroshige Yamabe; Takaaki Akaike
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-7
Journal Detail:
Title:  Microbiology and immunology     Volume:  -     ISSN:  1348-0421     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703966     Medline TA:  Microbiol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Societies and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Microbiology, Department of Cardiovascular Medicine, Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan, and Department of Cardiac Arrhythmias, Kumamoto University Hospital, Kumamoto 860-8556, Japan.
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