Document Detail


Potential applications of miRNAs as diagnostic and prognostic markers in liver cancer.
MedLine Citation:
PMID:  23276918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary liver tumors are mainly represented by hepatocellular hepatocarcinoma (HCC), one of the most aggressive and resistant forms of cancer. Numerous studies have reported the key role of microRNAs (miRNAs) in development, cell proliferation, apoptosis, and tumor biology. The alteration of cancer-related miRNA expression can be associated with tumorigenesis. In HCC, deregulated miRNAs frequently act as oncogenes or altered tumor suppressors. Distinct subtypes of hepatic cancer can also be related to an aberrant expression of particular miRNAs, arguing for the significance of using miRNAs as tumor biomarkers in order to refine the HCC grading assessment. In this article, we review the latest reports regarding miRNA profiling and the potential of small RNAs in HCC diagnosis. The relevance of cancer-related miRNA signatures for the prognosis and better understanding of liver cancer outcome is then considered.
Authors:
Luc Gailhouste; Laura Gomez-Santos; Takahiro Ochiya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-223     Citation Subset:  IM    
Affiliation:
Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / genetics
Carcinoma, Hepatocellular / diagnosis*,  etiology,  metabolism
Exosomes / metabolism
Fatty Liver / complications
Fatty Liver, Alcoholic / complications
Hepatitis B, Chronic / complications
Hepatitis C, Chronic / complications
Humans
Liver Cirrhosis / complications
Liver Neoplasms / diagnosis*,  etiology
MicroRNAs / biosynthesis,  diagnostic use*
Prognosis
Tumor Markers, Biological / blood,  genetics
Chemical
Reg. No./Substance:
0/MIRN122 microRNA, human; 0/MicroRNAs; 0/Tumor Markers, Biological

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