Document Detail

Potential application of poly(N-isopropylacrylamide) gel containing polymeric micelles to drug delivery systems.
MedLine Citation:
PMID:  16300934     Owner:  NLM     Status:  MEDLINE    
We have investigated rapidly thermo-responsive NIPA gel containing polymer surfactant PMDP (NIPA-PMDP gel) as a potential drug carrier using (+)-l-ascorbic acid as a model drug. In the NIPA-PMDP gel system micelles of polymer surfactant PMDP are trapped by the entanglement of polymer chains inside the gel networks. Therefore, in principle the gel system tightly stores targeted drug in the micelles and rapidly releases controlled amount of the drug by switching on-off of external stimuli such as temperature or infrared laser beam. In our investigation on release profile, the NIPA-PMDP gel system showed completely different releasing behavior from that of the conventional NIPA gel. The NIPA-PMDP gel released rapidly all loaded (+)-l-ascorbic acid above the phase transition temperature (ca. 34 degrees C), while slowly released the corresponding amount of the drug below the temperature. In contrast, the conventional NIPA gel released more slowly limited amount of the drug above the phase transition temperature while similarly did to the NIPA-PMDP gel below the temperature. The release profile of the NIPA-PMDP gel seems to be governed by only kinetics of volume phase transition of the gel network but not by the hydrophobic domains of the micelles probably because of too hydrophilic nature of (+)-l-ascorbic acid.
Hu Yan; Kaoru Tsujii
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-21
Journal Detail:
Title:  Colloids and surfaces. B, Biointerfaces     Volume:  46     ISSN:  0927-7765     ISO Abbreviation:  Colloids Surf B Biointerfaces     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-03-28     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9315133     Medline TA:  Colloids Surf B Biointerfaces     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  142-6     Citation Subset:  IM    
Nanotechnology Research Center, Research Institute for Electronic Science, Hokkaido University, Sapporo 001-0021, Japan.
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MeSH Terms
Acrylic Resins / chemistry*
Drug Carriers*
Reg. No./Substance:
0/Acrylic Resins; 0/Drug Carriers; 0/Micelles; 25189-55-3/poly-N-isopropylacrylamide

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