| Potential of antiviral therapy and prophylaxis for controlling RNA viral infections of livestock. | |
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MedLine Citation:
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PMID: 18035428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With intensification of trade, livestock are increasingly exposed to severe animal diseases caused by a range of RNA viruses. Recent prime examples include outbreaks of foot-and-mouth disease (FMD), peste des petits ruminants, Rift Valley fever and bluetongue. To minimise their impact, controlling the spread of virus is of utmost importance. Good quality, reliable vaccines exist for some, although not all, of these diseases, but suffer from a set of drawbacks, not the least of which being the time needed to trigger the immune response (i.e. "immunity-gap"). Effective, rapid control tools are, therefore, urgently needed and antiviral compounds could serve this purpose. Although limited in vitro and in vivo research has been performed, encouraging results for FMD suggest that livestock could be protected against infection within 24h following antiviral treatment and up to 12h post-infection. Such prophylactic/therapeutic antiviral drugs could complement emergency vaccination in a previously disease-free setting or be applied to treat valuable zoological collections and breeding stocks in endemic and previously disease-free regions alike. This paper will primarily focus on the effects of FMD on livestock and other sectors, and on appropriate control tools. The outlined principles can be extrapolated to other RNA viral diseases. |
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Authors:
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Nesya Goris; Frank Vandenbussche; Kris De Clercq |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2007-11-05 |
Journal Detail:
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Title: Antiviral research Volume: 78 ISSN: 0166-3542 ISO Abbreviation: Antiviral Res. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-18 Completed Date: 2008-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109699 Medline TA: Antiviral Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 170-8 Citation Subset: IM |
Affiliation:
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Department of Virology, Epizootic Diseases Section, Veterinary and Agrochemical Research Centre, Groeselenberg 99, 1180 Brussels, Belgium. negor@var.fgov.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Domestic / virology* Antiviral Agents / therapeutic use* Cattle Chemoprevention* Foot-and-Mouth Disease / drug therapy, prevention & control*, virology Foot-and-Mouth Disease Virus / classification, drug effects*, pathogenicity RNA Virus Infections / drug therapy, prevention & control, veterinary, virology RNA Viruses / classification, drug effects Viral Vaccines / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Viral Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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