Document Detail


Potential anti-inflammatory effects of 5-lipoxygenase inhibition--exemplified by the leukotriene synthesis inhibitor BAY X 1005.
MedLine Citation:
PMID:  9444606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leukotrienes have been identified in various pathophysiologies. The leukotrienes LTB4 and LTC4 are assigned to inflammation. 5-lipoxygenase inhibitors which inhibit the synthesis of LTA4 being the precursor of both LTB4 and LTC4 appear to have only a limited antiinflammatory potential. 5-lipoxygenase inhibitors are represented by direct and indirect inhibitors, the latter competing with substrate transfer from the five-lipoxygenase activating protein (FLAP) to the 5-lipoxygenase enzyme. 5-lipoxygenase inhibition under experimental condition results in inhibition of edema formation, neutrophil infiltration, smooth muscle contraction after antigen challenge and prevention of early and late allergic reactions. Only in the cysteinyl-leukotriene-driven pathophysiology of allergic asthma and allergic rhinitis 5-lipoxygenase inhibition appears to provide symptomatic relief. Yet, the overall-antiinflammatory effect in man in far less than expected, but may be outweighed by the nearly total lack of any side effects of 5-lipoxygenase inhibition per se.
Authors:
R Müller-Peddinghaus
Related Documents :
6097546 - Activation of the human neutrophil secretory process with 5(s),12(r)-dihydroxy-6,14-cis...
17323856 - Production of leukotriene c4 by peripheral blood leukocytes stimulated with anti-fcepsi...
8406156 - In vivo rectal inflammatory mediator changes with radiotherapy to the pelvis.
23087356 - Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intralumina...
2956836 - Role of platelets and thrombosis in mechanisms of acute occlusion and restenosis after ...
6517266 - Pathophysiology of haemorrhagic shock.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  48     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-03     Completed Date:  1998-03-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  529-36     Citation Subset:  IM    
Affiliation:
BAYER AG, Business Group Pharma Institute for Cardiovascular and Arteriosclerosis Research Wuppertal, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Humans
Inflammation / drug therapy
Lipoxygenase Inhibitors / therapeutic use*
Quinolines / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Lipoxygenase Inhibitors; 0/Quinolines; 128253-31-6/2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of free radicals in septic shock.
Next Document:  Mechanisms of acute respiratory distress syndrome: role of surfactant changes and mechanical ventila...