Document Detail

Potential targets for intervention in radiation-induced heart disease.
MedLine Citation:
PMID:  20583977     Owner:  NLM     Status:  MEDLINE    
Radiotherapy of thoracic and chest wall tumors, if all or part of the heart was included in the radiation field, can lead to radiation-induced heart disease (RIHD), a late and potentially severe side effect. RIHD presents clinically several years after irradiation and manifestations include accelerated atherosclerosis, pericardial and myocardial fibrosis, conduction abnormalities, and injury to cardiac valves. The pathogenesis of RIHD is largely unknown, and a treatment is not available. Hence, ongoing pre-clinical studies aim to elucidate molecular and cellular mechanisms of RIHD. Here, an overview of recent pre-clinical studies is given, and based on the results of these studies, potential targets for intervention in RIHD are discussed.
M Boerma; M Hauer-Jensen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current drug targets     Volume:  11     ISSN:  1873-5592     ISO Abbreviation:  Curr Drug Targets     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-04-21     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  100960531     Medline TA:  Curr Drug Targets     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1405-12     Citation Subset:  IM    
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MeSH Terms
Heart / radiation effects*
Heart Diseases / etiology*,  pathology,  prevention & control,  therapy*
Radiation Injuries / pathology,  prevention & control,  therapy*
Grant Support
CA71382/CA/NCI NIH HHS; CA83719/CA/NCI NIH HHS; R01 CA083719/CA/NCI NIH HHS; R01 CA083719-10/CA/NCI NIH HHS; R37 CA071382/CA/NCI NIH HHS; R37 CA071382-14/CA/NCI NIH HHS

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