Document Detail


The potential role of aerobic exercise to modulate cardiotoxicity of molecularly targeted cancer therapeutics.
MedLine Citation:
PMID:  23335619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Molecularly targeted therapeutics (MTT) are the future of cancer systemic therapy. They have already moved from palliative therapy for advanced solid malignancies into the setting of curative-intent treatment for early-stage disease. Cardiotoxicity is a frequent and potentially serious adverse complication of some targeted therapies, leading to a broad range of potentially life-threatening complications, therapy discontinuation, and poor quality of life. Low-cost pleiotropic interventions are therefore urgently required to effectively prevent and/or treat MTT-induced cardiotoxicity. Aerobic exercise therapy has the unique capacity to modulate, without toxicity, multiple gene expression pathways in several organ systems, including a plethora of cardiac-specific molecular and cell-signaling pathways implicated in MTT-induced cardiac toxicity. In this review, we examine the molecular signaling of antiangiogenic and HER2-directed therapies that may underpin cardiac toxicity and the hypothesized molecular mechanisms underlying the cardioprotective properties of aerobic exercise. It is hoped that this knowledge can be used to maximize the benefits of small molecule inhibitors, while minimizing cardiac damage in patients with solid malignancies.
Authors:
Jessica M Scott; Susan Lakoski; John R Mackey; Pamela S Douglas; Mark J Haykowsky; Lee W Jones
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2013-01-18
Journal Detail:
Title:  The oncologist     Volume:  18     ISSN:  1549-490X     ISO Abbreviation:  Oncologist     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-12-12     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9607837     Medline TA:  Oncologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inhibitors / adverse effects,  therapeutic use
Exercise / physiology*
Heart Diseases / chemically induced*,  therapy*
Humans
Neoplasms / drug therapy,  pathology,  therapy*
Receptor, erbB-2 / administration & dosage,  antagonists & inhibitors,  metabolism,  therapeutic use*
Grant Support
ID/Acronym/Agency:
CA133895/CA/NCI NIH HHS; CA138634/CA/NCI NIH HHS; CA142566/CA/NCI NIH HHS; CA143254/CA/NCI NIH HHS; CA164751/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; EC 2.7.10.1/ERBB2 protein, human; EC 2.7.10.1/Receptor, erbB-2
Comments/Corrections

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