Document Detail

Potential quantitative magnetic resonance imaging biomarkers of coronary remodeling in older hypertensive patients.
MedLine Citation:
PMID:  22539599     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To detect differences in potential magnetic resonance imaging biomarkers of coronary remodeling between older hypertensive patients and healthy controls.
METHODS AND RESULTS: Two-dimensional black-blood coronary wall magnetic resonance imaging and 3-dimensional whole-heart coronary magnetic resonance angiography were performed on 130 participants (65-84 years), including 65 hypertensive patients and 65 healthy controls. Coronary segments derived from hypertensive participants had a higher mean coronary wall thickness, a smaller vessel area, a smaller coronary wall area, a smaller lumen area, a lower coronary distensibility index, and a higher percent of the coronary wall occupying the vessel area (PWOV) than those from healthy controls. When the average PWOV was set as an ad hoc cutoff point, coronary segments with a high PWOV had a significantly higher mean wall thickness, a higher maximum wall thickness, a smaller vessel area, a smaller lumen area, a lower coronary distensibility index, and a higher coronary plaque index compared with coronary segments with a low PWOV.
CONCLUSIONS: Magnetic resonance techniques are able to noninvasively detect significant differences in potential imaging biomarkers of coronary remodeling between older hypertensive patients and healthy controls. The PWOV is a promising remodeling feature for quantitatively evaluating the progression of coronary atherosclerosis.
Kai Lin; Donald M Lloyd-Jones; Ying Liu; Xiaoming Bi; Debiao Li; James C Carr
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-26
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  32     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-08-23     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1742-7     Citation Subset:  IM    
Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
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MeSH Terms
Aged, 80 and over
Biological Markers
Coronary Artery Disease / diagnosis*
Coronary Vessels / pathology*
Hypertension / pathology*
Magnetic Resonance Imaging / methods*
Grant Support
Reg. No./Substance:
0/Biological Markers

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