| A potential and novel therapy for obesity: "appendix" electrical stimulation in dogs. | |
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MedLine Citation:
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PMID: 20890772 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Intestinal electrical stimulation (IES) has been introduced as a potential therapy for obesity. However, it is unknown whether the effects of IES on gastrointestinal motility and food intake are location-specific. The aim of this study was to assess the effects of "appendix" (cecum in dog) electrical stimulation (AES) on gastric tone, gastric emptying, and food intake in dogs. METHODS: Twelve healthy dogs were used in three experiments. In experiments 1 and 2, gastric tone and food intake were studied in six dogs implanted with a gastric cannula and one pair of stimulation electrodes in the "appendix." Experiment 3 was performed to study gastric emptying in six dogs with a duodenal cannula and one pair of stimulation electrodes in the "appendix." RESULTS: (1) AES resulted in proximal gastric distention, with gastric volume increased from 114.9 ± 10.7 mL at baseline to 301.7 ± 37.1 mL during AES (p = 0.001), and the effect was completely blocked by a nitric oxide synthase inhibitor. (2) Gastric emptying was delayed at 90 min from 69.8 ± 9.5% in the control session to 15.2 ± 3.6% in the AES session (p = 0.002). 3) AES reduced food intake (average daily intake over a 1-week period) by 55.4% (550.4 ± 17.6 g at control vs. 245.7 ± 17.1 g with AES, p < 0.001). CONCLUSIONS: AES reduces gastric tone via the nitrergic pathway, delays gastric emptying, and inhibits food intake in healthy dogs. These data suggest the therapeutic potential of AES for obesity. Additionally, AES is technically more feasible than electrical stimulation of the stomach or duodenum because a stimulator with electrodes may be placed into the appendix via colonoscopy. |
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Authors:
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Yong Lei; Jiande D Z Chen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obesity surgery Volume: 21 ISSN: 1708-0428 ISO Abbreviation: Obes Surg Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106714 Medline TA: Obes Surg Country: United States |
Other Details:
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Languages: eng Pagination: 397-403 Citation Subset: IM |
Affiliation:
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Veterans Research Foundation, VA Medical Center, Oklahoma City, OK, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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