| Potential In Vivo UVC Disinfection of Catheter Lumens: Estimation of the Doses Received by the Blood Flow Outside the Catheter Tip Hole. | |
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MedLine Citation:
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PMID: 21208210 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have demonstrated that it is possible to launch UVC LED light into bacterial contaminated polymer tubes/catheters and disinfect the intraluminal space of these tubes. This can be achieved by UVC treatment of the catheters on a regular basis. Catheters are in the distal end equipped with an exit hole for administration of drugs, bloods or nutrients into the bloodstream. Even if the UVC light is strongly attenuated during its propagation through the catheter tube a fraction of the UVC launched into the catheter will escape through the exit hole and irradiate the blood. We demonstrate by calculations that very small effective doses are exposed to the blood (ca 10(-4) J m(-2) ). This dosage level is very low compared with UVC doses reported from other therapeutic applications. The very short residence time of the blood constituents in the irradiated volume in front of the exit hole is the main reason why the UVC exposure to the blood in the catheter application is so low. The very low dose received by the blood through the catheter tip indicated that possible side effects are negligible and makes the UV disinfection technique feasible in a clinical setting. |
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Authors:
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Jimmy Bak; Thomas M Jørgensen; Jurgen Helfmann; Ute Gravemann; Inessa Vorontsova |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-5 |
Journal Detail:
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Title: Photochemistry and photobiology Volume: - ISSN: 1751-1097 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376425 Medline TA: Photochem Photobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Jimmy Bak. Photochemistry and Photobiology © 2011 The American Society of Photobiology. |
Affiliation:
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DTU Fotonik, Technical University of Denmark, Roskilde, Denmark Laser- und Medizin-Technologie GmbH (LMTB), Berlin, Germany Blood Center of the German Red Cross (NSTOB), Springe, Germany Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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