| Potential Implications of Coronary Artery Calcium Testing for Guiding Aspirin Use Among Asymptomatic Individuals With Diabetes Mellitus. | |
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MedLine Citation:
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PMID: 22228745 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVEIt is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain.RESEARCH DESIGN AND METHODSOf 44,052 asymptomatic individuals referred for CAC testing, we studied 2,384 individuals with diabetes. Subjects were followed for a mean of 5.6 ± 2.6 years for the end point of all-cause mortality.RESULTSThere were 162 deaths (6.8%) in the population. CAC was a strong predictor of mortality across age groups (age <50, 50-59, ≥60), sex, and risk factor burden (0 vs. ≥1 additional risk factor). In individuals without a clear indication for aspirin per current guidelines, CAC stratified risk, identifying patients above and below the 10% risk threshold of presumed aspirin benefit.CONCLUSIONSCAC can help risk stratify individuals with diabetes and may aid in selection of patients who may benefit from therapies such as low-dose aspirin for primary prevention. |
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Authors:
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Michael Gordon Silverman; Michael J Blaha; Matthew J Budoff; Juan J Rivera; Paolo Raggi; Leslee J Shaw; Daniel Berman; Tracy Callister; John A Rumberger; Jamal S Rana; Roger S Blumenthal; Khurram Nasir |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-6 |
Journal Detail:
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Title: Diabetes care Volume: - ISSN: 1935-5548 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, Maryland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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