| Potential of Electron Beam Computed Tomography for Coronary Artery Calcium Screening to Evaluate Fatty Liver: Comparison With 1H Magnetic Resonance Spectroscopy in the Dallas Heart Study. | |
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MedLine Citation:
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PMID: 21441828 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES:: Electron beam computed tomography (EBCT) for coronary artery calcification can potentially evaluate liver fat, another marker of cardiovascular risk. We compared quantitative estimates of hepatic steatosis measured by EBCT with those obtained by a well-validated, accurate-measure, magnetic resonance spectroscopy (H MRS). METHODS:: EBCT and H MRS were performed in 2159 subjects from the Dallas Heart Study. Forty subjects were randomly selected from each of 5 subgroups of liver fat percent by H MRS (n = 200). EBCT average liver attenuation (HU) was determined in a 1- to 2-cm circular region of interest over the liver lobes. Pearson correlation coefficients were calculated. Using a previously defined H MRS hepatic steatosis cut point (>5.5%), an optimized EBCT liver attenuation cut point was determined by receiver operating characteristic analysis. RESULTS:: H MRS liver fat content and EBCT average right lobe liver attenuation were moderately negatively correlated (r = -0.64, P < 0.0001) in all subjects and in those with H MRS hepatic steatosis (r = -0.71, P < 0.0001). This correlation did not improve with attenuation correction of the EBCT data using a standard calcium phantom or statistical transformation. Using an optimized receiver operating characteristic EBCT cut point (64.5 HU), sensitivity was 78% and specificity was 72% for detecting H MRS hepatic steatosis, with a high false negative rate. Risk factors for hepatic steatosis (obesity, diabetes mellitus, insulin resistance, metabolic syndrome) were more strongly correlated with H MRS than EBCT liver fat measures. CONCLUSIONS:: Liver attenuation on EBCT acquired for coronary artery calcification screening correlates modestly with H MRS measures of liver fat content, with a high false negative rate. |
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Authors:
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Susan Matulevicius; Laura C Huff; Lidia S Szczepaniak; Colby R Ayers; Matthew Budoff; Roderick McColl; Amit Khera; Ronald M Peshock |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-25 |
Journal Detail:
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Title: Journal of investigative medicine : the official publication of the American Federation for Clinical Research Volume: - ISSN: 1708-8267 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501229 Medline TA: J Investig Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Department of Internal Medicine, Division of Cardiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX; †Donald W. Reynolds Cardiovascular Clinical Research Center, Dallas, TX; ‡Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA; §Department of Internal Medicine, Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor - UCLA, Torrance, CA; and ∥Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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