| Potential Effect of Anti-Inflammatory Treatment on Reducing the Cardiovascular Risk in Rheumatoid Arthritis. | |
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MedLine Citation:
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PMID: 22272912 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis with an increased mortality burden, largely attributable to cardiovascular disease. There is extensive evidence that patients with RA experience accelerated atherosclerosis, which is considered as the main responsible of this increased cardiovascular burden. Nowadays atherosclerosis is regarded as an inflammatory condition: hence, the cumulative inflammatory burden of RA, with the abundant synthesis of proinflammatory cytokines, contributes directly to the early formation of the atheromatic plaque. It is therefore reasonable to postulate that, by alleviating inflammation, drugs commonly used in RA treatment may ameliorate the cardiovascular profile of these patients. Here we provide an extensive review of the literature, focusing on the effects of the available anti-rheumatic agents on cardiovascular mortality and morbidity among RA sufferers. |
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Authors:
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Cecilia Chighizola; Tommaso Schioppo; Francesca Ingegnoli; Pier Luigi Meroni |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-20 |
Journal Detail:
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Title: Current vascular pharmacology Volume: - ISSN: 1875-6212 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101157208 Medline TA: Curr Vasc Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Rheumatology, Istituto Ortopedico Gaetano Pini, Piazza A. Cardinal Ferrari 1, 20122 Milan, Italy. pierluigi.meroni@unimi.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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