Document Detail

Potential correlation between carboxylic acid metabolites in Biomphalaria alexandrina snails after exposure to Schistosoma mansoni infection.
MedLine Citation:
PMID:  22711922     Owner:  NLM     Status:  MEDLINE    
Carboxylic acids play an important role in both aerobic and anaerobic metabolic pathways of both the snail and the parasite. Monitoring the effects of infection by schistosome on Biomphalaria alexandrina carboxylic acids metabolic profiles represents a promising additional source of information about the state of metabolic system. We separated and quantified pyruvic, fumaric, malic, oxalic, and acetic acids using ion-suppression reversed-phase high performance liquid chromatography (HPLC) to detect correlations between these acids in both hemolymph and digestive gland gonad complex (DGG's) samples in a total of 300 B. alexandrina snails (150 infected and 150 controls) at different stages of infection. The results showed that the majority of metabolite pairs did not show significant correlations. However, some high correlations were found between the studied acids within the control group but not in other groups. More striking was the existence of reversed correlations between the same acids at different stages of infection. Some possible explanations of the underlying mechanisms were discussed. Ultimately, however, further data are required for resolving the responsible regulatory events. These findings highlight the potential of metabolomics as a novel approach for fundamental investigations of host-pathogen interactions as well as disease surveillance and control.
Salwa M F Abou Elseoud; Nashwa S Abdel Fattah; Hayam M Ezz El Din; Hala Abdel Al; Hanan Mossalem; Noha Elleboudy
Publication Detail:
Type:  Journal Article     Date:  2012-05-24
Journal Detail:
Title:  The Korean journal of parasitology     Volume:  50     ISSN:  1738-0006     ISO Abbreviation:  Korean J. Parasitol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-19     Completed Date:  2012-10-17     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9435800     Medline TA:  Korean J Parasitol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  119-26     Citation Subset:  IM    
Parasitology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biomphalaria / chemistry*,  parasitology*
Carboxylic Acids / analysis*,  metabolism
Chromatography, High Pressure Liquid
Gastrointestinal Tract / chemistry
Hemolymph / chemistry
Schistosoma mansoni / chemistry*,  growth & development*
Reg. No./Substance:
0/Carboxylic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Positivity and intensity of Gnathostoma spinigerum infective larvae in farmed and wild-caught swamp ...
Next Document:  Seasonal abundance of biting midges, Culicoides spp. (Diptera: Ceratopogonidae), collected at cowshe...