| Potential CNS antitumor agents--phenothiazines I: Nitrogen mustard derivatives. | |
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MedLine Citation:
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PMID: 994007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four phenothiazine derivatives containing the bis(beta-chloroethyl)aminopropyl side chain were prepared and evaluated in the murine L-1210, P-388, and B-16 melanoma intraperitoneal tumor systems. Moderate P-388 activity was observed. An aminoethyl phenothiazine mustard was compared with the aminopropyl analogs and was superior in all test systems. None of the compounds tested against the murine ependymoblastoma brain tumor system was active. |
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Authors:
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T Hirata; J S Driscoll |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 65 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1976 Nov |
Date Detail:
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Created Date: 1977-01-29 Completed Date: 1977-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1699-701 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemical synthesis*, therapeutic use Brain Neoplasms / drug therapy Cell Line Ependymoma / drug therapy Leukemia, Experimental / drug therapy Melanoma / drug therapy Mice Neoplasms, Experimental / drug therapy Nitrogen Mustard Compounds / chemical synthesis*, therapeutic use Phenothiazines / chemical synthesis*, therapeutic use Psychotropic Drugs / chemical synthesis*, therapeutic use Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Nitrogen Mustard Compounds; 0/Phenothiazines; 0/Psychotropic Drugs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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