Document Detail

Potential CNS antitumor agents--phenothiazines I: Nitrogen mustard derivatives.
MedLine Citation:
PMID:  994007     Owner:  NLM     Status:  MEDLINE    
Four phenothiazine derivatives containing the bis(beta-chloroethyl)aminopropyl side chain were prepared and evaluated in the murine L-1210, P-388, and B-16 melanoma intraperitoneal tumor systems. Moderate P-388 activity was observed. An aminoethyl phenothiazine mustard was compared with the aminopropyl analogs and was superior in all test systems. None of the compounds tested against the murine ependymoblastoma brain tumor system was active.
T Hirata; J S Driscoll
Related Documents :
16404347 - Evaluation of fluorenhymustine as a rationally designed novel anticancer agent.
24722987 - The e3 ubiquitin protein ligase herc2 modulates activity of tumor protein p53 by regula...
24686897 - Radiotherapy-induced anti-tumor immunity contributes to the therapeutic efficacy of irr...
18472797 - Anti-tumor activity, in vitro and in vivo, of some triphenylphosphinegold(i) thionucleo...
21057127 - Hypervascular subepithelial gastrointestinal masses: ct-pathologic correlation.
12481437 - Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated an...
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  65     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-01-29     Completed Date:  1977-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1699-701     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents / chemical synthesis*,  therapeutic use
Brain Neoplasms / drug therapy
Cell Line
Ependymoma / drug therapy
Leukemia, Experimental / drug therapy
Melanoma / drug therapy
Neoplasms, Experimental / drug therapy
Nitrogen Mustard Compounds / chemical synthesis*,  therapeutic use
Phenothiazines / chemical synthesis*,  therapeutic use
Psychotropic Drugs / chemical synthesis*,  therapeutic use
Structure-Activity Relationship
Reg. No./Substance:
0/Antineoplastic Agents; 0/Nitrogen Mustard Compounds; 0/Phenothiazines; 0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quantitative determination of morphine in paregoric USP by high-pressure liquid chromatography.
Next Document:  Enhancement of dissolution rates of poorly water-soluble drugs by crystallization in aqueous surfact...