Document Detail


Potential CNS antitumor agents--phenothiazines I: Nitrogen mustard derivatives.
MedLine Citation:
PMID:  994007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four phenothiazine derivatives containing the bis(beta-chloroethyl)aminopropyl side chain were prepared and evaluated in the murine L-1210, P-388, and B-16 melanoma intraperitoneal tumor systems. Moderate P-388 activity was observed. An aminoethyl phenothiazine mustard was compared with the aminopropyl analogs and was superior in all test systems. None of the compounds tested against the murine ependymoblastoma brain tumor system was active.
Authors:
T Hirata; J S Driscoll
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  65     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-01-29     Completed Date:  1977-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1699-701     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemical synthesis*,  therapeutic use
Brain Neoplasms / drug therapy
Cell Line
Ependymoma / drug therapy
Leukemia, Experimental / drug therapy
Melanoma / drug therapy
Mice
Neoplasms, Experimental / drug therapy
Nitrogen Mustard Compounds / chemical synthesis*,  therapeutic use
Phenothiazines / chemical synthesis*,  therapeutic use
Psychotropic Drugs / chemical synthesis*,  therapeutic use
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Nitrogen Mustard Compounds; 0/Phenothiazines; 0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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