| The potential adverse role of leptin resistance in nonalcoholic Fatty liver disease: a hypothesis based on critical review of the literature. | |
| | |
MedLine Citation:
|
PMID: 20717042 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Leptin is an adipocyte-derived hormone that plays a crucial role in energy homeostasis and lipid metabolism. Most of the biological effects of leptin are exerted through activation of the Janus kinase-2/signal transducer and activator of transcription-3 pathway. Signal transducer and activator of transcription-3 activation ultimately leads to an increased transcription and expression of suppressors of cytokine signaling-3, which acts as a feedback inhibitor by attenuating leptin signaling. Apart from inhibiting leptin signaling, suppressor of cytokine signaling-3 inhibits insulin signaling. Leptin increases with increasing fatty mass as a compensatory mechanism to preserve insulin sensitivity, but persistent hyperleptinemia is implicated in liver fibrinogenesis and carcinogenesis. HYPOTHESIS: Considering this dual role of leptin in the liver pathophysiology, we hypothesized that leptin resistance may vary according to the different types of liver cells and nonalcoholic fatty liver disease progression. CLINICAL CONSEQUENCES: It is speculated that recombinant leptin, proposed to be used in common forms of obesity or nonalcoholic fatty liver disease, might have serious unfavorable therapeutical drawbacks, through promotion of insulin resistance, fibrosis, and hepatocellular carcinoma. |
| | |
Authors:
|
Stergios A Polyzos; Jannis Kountouras; Christos Zavos; Georgia Deretzi |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of clinical gastroenterology Volume: 45 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 50-4 Citation Subset: IM |
Affiliation:
|
*Second Medical Clinic, Medical School, Aristotle University of Thessaloniki, Ippokration Hospital †Department of Neurology, Papageorgiou General Hospital, Thessaloniki, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Consumer perceptions of direct-to-consumer personalized genomic risk assessments.
Next Document: Genetic predisposition to thrombophilia in inflammatory bowel disease.