Document Detail

Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma.
MedLine Citation:
PMID:  11786418     Owner:  NLM     Status:  MEDLINE    
The tall-cell variant (TCV) of papillary thyroid carcinoma (PTC), characterized by tall cells bearing an oxyphilic cytoplasm, is more clinically aggressive than conventional PTC. RET tyrosine kinase rearrangements, which represent the most frequent genetic alteration in PTC, lead to the recombination of RET with heterologous genes to generate chimeric RET/PTC oncogenes. RET/PTC1 and RET/PTC3 are the most prevalent variants. We have found RET rearrangements in 35.8% of TCV (14 of 39 cases). Whereas the prevalences of RET/PTC1 and RET/PTC3 were almost equal in classic and follicular PTC, all of the TCV-positive cases expressed the RET/PTC3 rearrangement. These findings prompted us to compare RET/PTC3 and RET/PTC1 in an in vitro thyroid model system. We have expressed the two oncogenes in PC Cl 3 rat thyroid epithelial cells and found that RET/PTC3 is endowed with a strikingly more potent mitogenic effect than RET/PTC1. Mechanistically, this difference correlated with an increased signaling activity of RET/PTC3. In conclusion, we postulate that the correlation between the RET/PTC rearrangement type and the aggressiveness of human PTC is related to the efficiency with which the oncogene subtype delivers mitogenic signals to thyroid cells.
Fulvio Basolo; Riccardo Giannini; Carmen Monaco; Rosa Marina Melillo; Francesca Carlomagno; Martina Pancrazi; Giuliana Salvatore; Gennaro Chiappetta; Furio Pacini; Rossella Elisei; Paolo Miccoli; Aldo Pinchera; Alfredo Fusco; Massimo Santoro
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  160     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-11     Completed Date:  2002-07-05     Revised Date:  2012-06-01    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  AIM; IM    
Dipartimento di Oncologia, Università degli Studi di Pisa, Pisa. Fondazione Senatore Pascale, Naples, Italy.
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MeSH Terms
Carcinoma, Papillary / genetics*,  pathology*
Cell Line
Gene Frequency
Growth Substances / physiology*
Middle Aged
Oncogene Proteins, Fusion / physiology
Oncogenes / physiology*
Phosphoprotein Phosphatases / genetics*,  physiology
Protein Phosphatase 2
Protein-Tyrosine Kinases
Rats, Inbred F344
Saccharomyces cerevisiae Proteins*
Thyroid Neoplasms / genetics*,  pathology*
Reg. No./Substance:
0/Growth Substances; 0/Oncogene Proteins, Fusion; 0/Saccharomyces cerevisiae Proteins; EC Kinases; EC fusion oncoproteins, human; EC protein, S cerevisiae; EC Phosphatases; EC Phosphatase 2; EC phosphatase 2C

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